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Anti-Mycobacterial Activity of Tamoxifen Against Drug-Resistant and Intra-Macrophage Mycobacterium tuberculosis
- Authors
- Jang, Woong Sik; Kim, Sukyung; Podder, Biswajit; Jyoti, Md Anirban; Nam, Kung-Woo; Lee, Byung-Eui; Song, Ho-Yeon
- Issue Date
- Jun-2015
- Publisher
- 한국미생물·생명공학회
- Keywords
- Mycobacterium tuberculosis; tamoxifen; intracellular killing; MDR; XDR
- Citation
- Journal of Microbiology and Biotechnology, v.25, no.6, pp 946 - 950
- Pages
- 5
- Journal Title
- Journal of Microbiology and Biotechnology
- Volume
- 25
- Number
- 6
- Start Page
- 946
- End Page
- 950
- ISSN
- 1017-7825
1738-8872
- Abstract
- Recently, it has become a struggle to treat tuberculosis with the current commercial anti-tuberculosis drugs because of the increasing emergence of multidrug-resistant (MDR) tuberculosis and extensively drug-resistant (XDR) tuberculosis. We evaluated here the anti-mycobacterial activity of tamoxifen, known as a synthetic anti-estrogen, against eight drug-sensitive or resistant strains of Mycobacterium tuberculosis (TB), and the active intracellular killing of tamoxifen on TB in macrophages. The results showed that tamoxifen had anti-tuberculosis activity against drug-sensitive strains (MIC, 3.125-6.25 mu g/ml) as well as drug-resistant strains (MIC, 6.25 to 12.5 mu g/ml). In addition, tamoxifen profoundly decreased the number of intracellular TB in macrophages in a dose-dependent manner.
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Related Researcher
- Nam, Kung woo
- Industry-University Cooperation Foundation