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Anti-inflammatory activity of sappanchalcone isolated from Caesalpinia sappan L. in a collagen-induced arthritis mouse model

Authors
Jung, Eui-GilHan, Kook-IlKwon, Hyun-JungPatnaik, Bharat BhusanKim, Wan-JongHur, Gang MinNam, Kung-WooHan, Man-Deuk
Issue Date
Jun-2015
Publisher
대한약학회
Keywords
Caesalpinia sappan L.; Sappanchalcone; Collagen-induced arthritis; Inflammatory cytokines; Arthritis score; Rheumatoid arthritis
Citation
Archives of Pharmacal Research, v.38, no.6, pp 973 - 983
Pages
11
Journal Title
Archives of Pharmacal Research
Volume
38
Number
6
Start Page
973
End Page
983
URI
https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/10635
DOI
10.1007/s12272-015-0557-z
ISSN
0253-6269
1976-3786
Abstract
Sappanchalcone, a bioactive flavonoid isolated from the heartwood of Caesalpinia sappan L. possesses anti-inflammatory effects. We studied the efficacy of sappanchalcone in attenuating collagen-induced arthritis (CIA) in a mouse model of rheumatoid arthritis. Sappanchalcone was purified to homogeneity from the chloroform fraction of the methanolic extract of C. sappan, and identified using mass spectrometry and H-1-nuclear magnetic resonance spectroscopy. CIA-induced male DBA/1J mice were divided into control, sappanchalcone-treated, and methotrexate-treated groups (n = 10 per group). Paw swelling, arthritis severity, radiographic and histomorphometric changes were assessed to measure the protective role of sappanchalcone against chronic disease progression. Sappanchalcone administration significantly reduced clinical arthritis and inflammatory edema in paws. Bone mineral density and trabecular structure were maintained in CIA mice administered sappanchalcone. The levels of pro-inflammatory cytokines (TNF-alpha, IL-6, and 1L-1 beta) were significantly lower in the serum of sappanchalcone-treated mice as compared with the control group. Our results suggest that sappanchalcone could be used as an anti-inflammatory and bone-protective agent during the treatment of rheumatoid arthritis.
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