IBX-Mediated Oxidation and Internal Redox Reaction Cascade: Asymmetric One-Pot Synthesis of Ring-fused Tetrahydroquinolines

Abstract

Organocatalytic asymmetric synthesis of tetrahydroquinolines has been achieved via oxidation and 1,5-hydride transfer/ring-closure cascade. The feature of this research is one-pot transformation of 3-arylprop-2-en-1-ol derivatives into tetrahydroquinolines using o-iodoxybenzoic acid-mediated oxidation and internal redox reactions. The synthetically useful ring-fused tetrahydroquinoline derivatives were obtained in moderate yields and high enantioselectivity.