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Regulation of lipid production by light-emitting diodes in human sebocytes
- Authors
- Jung, Yu Ra; Kim, Sue Jeong; Sohn, Kyung Cheol; Lee, Young; Seo, Young Joon; Lee, Young Ho; Whang, Kyu Uang; Kim, Chang Deok; Lee, Jeung Hoon; Im, Myung
- Issue Date
- Apr-2015
- Publisher
- Springer Verlag
- Keywords
- Acne; LED; Sebocyte; Sebum
- Citation
- Archives of Dermatological Research, v.307, no.3, pp 265 - 273
- Pages
- 9
- Journal Title
- Archives of Dermatological Research
- Volume
- 307
- Number
- 3
- Start Page
- 265
- End Page
- 273
- ISSN
- 0340-3696
1432-069X
- Abstract
- Light-emitting diodes (LED) have been used to treat acne vulgaris. However, the efficacy of LED on sebaceous lipid production in vitro has not been examined. This study investigated the efficacy of 415 nm blue light and 630 nm red light on lipid production in human sebocytes. When applied to human primary sebocytes, 415 nm blue light suppressed cell proliferation. Based on a lipogenesis study using Oil Red O, Nile red staining, and thin-layered chromatography, 630 nm red light strongly downregulated lipid production in sebocytes. These results suggest that 415 nm blue light and 630 nm red light influence lipid production in human sebocytes and have beneficial effects on acne by suppressing sebum production.
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Collections - College of Medicine > Department of Dermatology > 1. Journal Articles
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