Risk of Malignancy in Thyroid Incidentalomas Identified by Fluorodeoxyglucose-Positron Emission Tomography
- Authors
- Chun, A. Reum; Jo, Hye Min; Lee, Seoung Ho; Chun, Hong Woo; Park, Jung Mi; Kim, Kyu Jin; Jung, Chan Hee; Mok, Ji Oh; Kang, Sung Koo; Kim, Chul Hee; Kim, Bo Yeon
- Issue Date
- Mar-2015
- Publisher
- 대한내분비학회
- Keywords
- Thyroid gland; Incidental findings; Fluorodeoxyglucose F18; Positron-emission tomography; Thyroid neoplasms; Prevalence
- Citation
- Endocrinology and Metabolism, v.30, no.1, pp 71 - 77
- Pages
- 7
- Journal Title
- Endocrinology and Metabolism
- Volume
- 30
- Number
- 1
- Start Page
- 71
- End Page
- 77
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/10859
- DOI
- 10.3803/EnM.2015.30.1.71
- ISSN
- 2093-596X
2093-5978
- Abstract
- Background: Thyroid incidentalomas detected by 2-deoxy-2-F-18-fluoro-D-glucose positron emission tomography/computed tomography (F-18-FDG PET/CT) have been reported in 1% to 4% of the population, with a risk of malignancy of 27.8% to 74%. We performed a retrospective review of FDG-avid thyroid incidentalomas in cancer screening subjects and patients with nonthyroid cancer. The risk of malignancy in thyroid incidentaloma and its association with the maximal standardized uptake value (SUVmax) in F-18-FDG PET/CT were evaluated to define the predictor variables in assessing risk of malignancy. Methods: A total of 2,584 subjects underwent F-18-FDG PET/CT for metastatic evaluation or cancer screening from January 2005 to January 2010. Among them, 36 subjects with FDG-avid thyroid incidentalomas underwent further diagnostic evaluation (thyroid ultrasonography-guided fine needle aspiration cytology [FNAC] or surgical resection). We retrospectively reviewed the database of these subjects. Results: Of the 2,584 subjects who underwent F-18-FDG PET/CT (319 for cancer screening and 2,265 for metastatic evaluation), 52 (2.0%) were identified as having FDG-avid thyroid incidentaloma and cytologic diagnosis was obtained by FNAC in 36 subjects. Of the subjects, 15 were proven to have malignant disease: 13 by FNAC and two by surgical resection. The positive predictive value of malignancy in FDG-avid thyroid incidentaloma was 41.7%. Median SUVmax was higher in malignancy than in benign lesions (4.7 [interquartile range (IQR), 3.4 to 6.0] vs. 2.8 [IQR, 2.6 to 4.0], P=0.001). Conclusion: Thyroid incidentalomas found on F-18-FDG PET/CT have a high risk of malignancy, with a positive predictive value of 41.7%. FDG-avid thyroid incidentalomas with higher SUVmax tended to be malignant.
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Collections - College of Medicine > Department of Internal Medicine > 1. Journal Articles
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