Suppressive effects of 1-[4-fluoro-2-(2-nitrovinyl)phenyl]pyrrolidine on the Toll-like receptor signaling pathways
DC Field | Value | Language |
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dc.contributor.author | Ahn, Sang-Il | - |
dc.contributor.author | Lim, Se Jin | - |
dc.contributor.author | Gu, Gyo-Jeong | - |
dc.contributor.author | Hong, Chae-Yeon | - |
dc.contributor.author | Kim, Ji-Soo | - |
dc.contributor.author | Jeong, Hyun Jung | - |
dc.contributor.author | Koh, Kwang Oh | - |
dc.contributor.author | Mang, Joo Yang | - |
dc.contributor.author | Kim, Dae Young | - |
dc.contributor.author | Youn, Hyung-Sun | - |
dc.date.accessioned | 2021-08-11T20:46:23Z | - |
dc.date.available | 2021-08-11T20:46:23Z | - |
dc.date.issued | 2015-01 | - |
dc.identifier.issn | 1567-5769 | - |
dc.identifier.issn | 1878-1705 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/10983 | - |
dc.description.abstract | When various pathogens invade a host, toll-like receptors (TLRs) play a significant role in recognizing the pathogen-associated molecular patterns carried by the pathogens to induce innate immune reaction, followed by acquired immunity reaction. TLRs have two downstream signaling pathways, the myeloid differential factor 88 (MyD88)-dependent and toll-interleukin-1 receptor domain-containing adapter inducing interferon-beta (TRIF)-dependent pathways. To evaluate the therapeutic potential of 1-[4-fluoro-2-(2-nitrovinyl)phenyl]pyrrolidine (FPP), previously synthesized in our laboratory, its effect on signal transduction via the TLR signaling pathways was examined. FPP inhibited the activation of nuclear factor-kappa B (NF-kappa B) and interferon regulatory factor 3 (IRF3) induced by TLR agonists, as well as inhibited the expression of cydooxygenase-2, inducible nitric oxide synthase, and interferon inducible protein-10. FPP also inhibited the activation of NF-kappa B and IRF3 when induced by the overexpression of downstream signaling components of the TLRs. As a result, FPP has potential to become a new therapeutic drug for many inflammatory diseases. (C) 2014 Elsevier B.V. All rights reserved. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier BV | - |
dc.title | Suppressive effects of 1-[4-fluoro-2-(2-nitrovinyl)phenyl]pyrrolidine on the Toll-like receptor signaling pathways | - |
dc.type | Article | - |
dc.publisher.location | 네델란드 | - |
dc.identifier.doi | 10.1016/j.intimp.2014.10.033 | - |
dc.identifier.scopusid | 2-s2.0-84911937181 | - |
dc.identifier.wosid | 000348621900005 | - |
dc.identifier.bibliographicCitation | International Immunopharmacology, v.24, no.1, pp 36 - 41 | - |
dc.citation.title | International Immunopharmacology | - |
dc.citation.volume | 24 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 36 | - |
dc.citation.endPage | 41 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | IFN-REGULATORY FACTOR-3 | - |
dc.subject.keywordPlus | TANK-BINDING KINASE-1 | - |
dc.subject.keywordPlus | SESQUITERPENE LACTONES | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | VIRAL-INFECTION | - |
dc.subject.keywordPlus | IKK-EPSILON | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | LIPOPOLYSACCHARIDE | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordAuthor | Toll-like receptor | - |
dc.subject.keywordAuthor | NF-kappa B | - |
dc.subject.keywordAuthor | IRF3 | - |
dc.subject.keywordAuthor | Cyclooxygenase-2 | - |
dc.subject.keywordAuthor | Inducible nitric oxide synthase | - |
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