Suppressive effects of 1-[4-fluoro-2-(2-nitrovinyl)phenyl]pyrrolidine on the Toll-like receptor signaling pathways
- Authors
- Ahn, Sang-Il; Lim, Se Jin; Gu, Gyo-Jeong; Hong, Chae-Yeon; Kim, Ji-Soo; Jeong, Hyun Jung; Koh, Kwang Oh; Mang, Joo Yang; Kim, Dae Young; Youn, Hyung-Sun
- Issue Date
- Jan-2015
- Publisher
- Elsevier BV
- Keywords
- Toll-like receptor; NF-kappa B; IRF3; Cyclooxygenase-2; Inducible nitric oxide synthase
- Citation
- International Immunopharmacology, v.24, no.1, pp 36 - 41
- Pages
- 6
- Journal Title
- International Immunopharmacology
- Volume
- 24
- Number
- 1
- Start Page
- 36
- End Page
- 41
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/10983
- DOI
- 10.1016/j.intimp.2014.10.033
- ISSN
- 1567-5769
1878-1705
- Abstract
- When various pathogens invade a host, toll-like receptors (TLRs) play a significant role in recognizing the pathogen-associated molecular patterns carried by the pathogens to induce innate immune reaction, followed by acquired immunity reaction. TLRs have two downstream signaling pathways, the myeloid differential factor 88 (MyD88)-dependent and toll-interleukin-1 receptor domain-containing adapter inducing interferon-beta (TRIF)-dependent pathways. To evaluate the therapeutic potential of 1-[4-fluoro-2-(2-nitrovinyl)phenyl]pyrrolidine (FPP), previously synthesized in our laboratory, its effect on signal transduction via the TLR signaling pathways was examined. FPP inhibited the activation of nuclear factor-kappa B (NF-kappa B) and interferon regulatory factor 3 (IRF3) induced by TLR agonists, as well as inhibited the expression of cydooxygenase-2, inducible nitric oxide synthase, and interferon inducible protein-10. FPP also inhibited the activation of NF-kappa B and IRF3 when induced by the overexpression of downstream signaling components of the TLRs. As a result, FPP has potential to become a new therapeutic drug for many inflammatory diseases. (C) 2014 Elsevier B.V. All rights reserved.
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Collections - College of Medical Sciences > Department of Biomedical Laboratory Science > 1. Journal Articles
- College of Natural Sciences > Department of Chemistry > 1. Journal Articles
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