Long-Term Outcomes and Dynamics of Mutants Associated with Lamivudine-Adefovir Rescue Therapy in Patients with Lamivudine-Resistant Chronic Hepatitis B
- Authors
- Kim, Jihyun; Lee, Sae Hwan; Kim, Hong Soo; Choi, Kanghyug; Jeong, Soung Won; Kim, Sang Gyune; Jang, Jae Young; Kim, Young Seok; Kim, Boo Sung
- Issue Date
- Jan-2015
- Publisher
- 거트앤리버 발행위원회
- Keywords
- Hepatitis B virus; Lamivudine resistance; Restriction fragment mass polymorphism; Mutation
- Citation
- Gut and Liver, v.9, no.1, pp 103 - 108
- Pages
- 6
- Journal Title
- Gut and Liver
- Volume
- 9
- Number
- 1
- Start Page
- 103
- End Page
- 108
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/11004
- DOI
- 10.5009/gnl14018
- ISSN
- 1976-2283
2005-1212
- Abstract
- Background/Aims: To investigate the association between the baseline profiles and dynamics of hepatitis B virus (HBV) DNA polymerase gene mutations and the long-term virological response of lamivudine (LAM)-adefovir (ADV) combination therapy in patients with LAM-resistant chronic hepatitis B. Methods: Seventy-five patients who received LAM-ADV combination therapy for more than 12 months were analyzed. Restriction fragment mass polymorphism assays were used to detect and monitor the dynamics of LAM- and ADV-resistant mutations. Results: The median duration of LAM-ADV combination therapy was 26 months (range, 12 to 58 months). The baseline mutation profiles, rtM2041(p=0.992), rtM204I/V (p=0.177), and rtL180M (p=0.051), were not correlated with the cumulative virological response, and the baseline HBV DNA level (p=0.032) was the only independent predictive factor for cumulative virological response. Tests for LAM- and ADV-resistant mutations were performed in 12 suboptimal responders in weeks 48 and 96. The population of rtM204 mutants persisted or increased in 8 of 12 patients, and rtA181T mutants newly emerged as a minor population in four patients until 96 weeks. Nevertheless, the viral loads progressively decreased during rescue therapy, and these dynamics did not correlate with virological response. Conclusions: The baseline profile and dynamics of LAM-resistant mutations during LAM-ADV combination therapy are not associated with a virological response.
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Collections - College of Medicine > Department of Internal Medicine > 1. Journal Articles
- College of Medicine > Department of Internal Medicine > 1. Journal Articles
- College of Medicine > Department of Internal Medicine > 1. Journal Articles
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