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Improved In Vitro Biocompatibility of Surface- Modified Hydroxyapatite Sponge Scaffold with Gelatin and BMP-2 in Comparison Against a Commercial Bone Allograft

Authors
Carpena, Nathaniel T.Min, Young-KiLee, Byong-Taek
Issue Date
Jan-2015
Publisher
American Society For Artificial Internal Organs
Keywords
biomaterials; bone regeneration; allograft; growth factor
Citation
ASAIO Journal, v.61, no.1, pp 78 - 86
Pages
9
Journal Title
ASAIO Journal
Volume
61
Number
1
Start Page
78
End Page
86
URI
https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/11033
DOI
10.1097/MAT.0000000000000155
ISSN
1058-2916
1538-943X
Abstract
This study aims to demonstrate the morphology and in vitro biocompatibility of neat and surface-modified hydroxyapatite sponge scaffold (SM-HASS) which was fabricated using a sponge replica method, and compared with the commercially available demineralized freeze-dried bone allograft (DFDBA). Surface-modifications were done by coating the surface area of the neat hydroxyapatite sponge scaffold (HASS) with either gelatin alone (HASS/G) or gelatin and BMP-2 growth factor (HASS/G+B). Scanning electron microscope (SEM), Fourier transform infrared (FTIR), porosity, pore size distribution, and compressive strength analyses showed that the addition of gelatin in HASS/G produced a morphologically and structurally similar scaffold to that of the allograft. The addition of BMP-2 improved the biocompatibility of the HASS/G+B in vitro using MC3T3-E1 cells which showed better cell viability, proliferation, and cell adhesion than on the allograft. Therefore, hydroxyapatite scaffold coated with gelatin polymer and gelatin with BMP-2 growth factor showed comparable performance against commercially available DFDBA from cadaver with regards to structure and in vitro biocompatibility.
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