Depression and Quality of Life in Patients with Systemic Lupus Erythematosus
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 장성혜 | - |
dc.contributor.author | 조자현 | - |
dc.contributor.author | 신나희 | - |
dc.contributor.author | 오혜진 | - |
dc.contributor.author | 최병용 | - |
dc.contributor.author | 윤명재 | - |
dc.contributor.author | 이은영 | - |
dc.contributor.author | 이은봉 | - |
dc.contributor.author | 이윤종 | - |
dc.contributor.author | 이태진 | - |
dc.contributor.author | 함봉진 | - |
dc.contributor.author | 송영욱 | - |
dc.date.accessioned | 2021-08-11T20:47:56Z | - |
dc.date.available | 2021-08-11T20:47:56Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 2093-940X | - |
dc.identifier.issn | 2233-4718 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/11121 | - |
dc.description.abstract | The objective of this study is to examine the prevalence of depression and its related factors including quality of life, brain-derived neurotrophic factor (BDNF), and vitamin D in patients with systemic lupus erythematosus (SLE). Methods. Depression was assessed using the center for epidemiologic studies depression (CES-D) scale. Disease activity, disease-related organ damage, the EuroQol-5 dimensions (EQ-5D), sociodemographic features, and laboratory tests including serum vitamin D level were surveyed. Serum BDNF was measured using an enzyme-linked immunosorbent assay. Results. Depression was observed in 22.8% of 180 SLE patients (n=41). Patients with marital status of single/divorced/separated/widowed, a higher patient global assessment (PGA) score, and extreme pain/discomfort showed significant association with depression. The EQ-5D index showed negative correlation with CES-D score (r=−0.56, p<0.05). In each EQ-5D dimension, depression showed significant association with moderate to severe problems in self-care and usual activities, and extreme pain/discomfort. Serum BDNF levels were not associated with depression (p=0.75) but associated with SLE disease activity index (SLEDAI; r=−0.21, p<0.05). Serum vitamin D levels were not associated with depression (p=0.60) but showed negative correlation with SLEDAI (r=−0.23, p<0.05) and mean glucocorticoid dose over the previous 3 months (r=−0.21, p<0.05) after adjustment for use of vitamin D supplement. Conclusion. Depression was prevalent in patients with SLE and was associated with low quality of life, and a higher PGA but not with SLEDAI. Serum BDNF and vitamin D levels were not associated with depression but showed negative correlation with SLEDAI. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한류마티스학회 | - |
dc.title | Depression and Quality of Life in Patients with Systemic Lupus Erythematosus | - |
dc.title.alternative | Depression and Quality of Life in Patients with Systemic Lupus Erythematosus | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.bibliographicCitation | 대한류마티스학회지, v.22, no.6, pp 346 - 355 | - |
dc.citation.title | 대한류마티스학회지 | - |
dc.citation.volume | 22 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 346 | - |
dc.citation.endPage | 355 | - |
dc.identifier.kciid | ART002061902 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | Systemic lupus erythematosus | - |
dc.subject.keywordAuthor | Depression | - |
dc.subject.keywordAuthor | Quality of life | - |
dc.subject.keywordAuthor | Brain-derived neurotrophic factor | - |
dc.subject.keywordAuthor | Vitamin D | - |
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