Depression and Quality of Life in Patients with Systemic Lupus ErythematosusDepression and Quality of Life in Patients with Systemic Lupus Erythematosus
- Other Titles
- Depression and Quality of Life in Patients with Systemic Lupus Erythematosus
- Authors
- 장성혜; 조자현; 신나희; 오혜진; 최병용; 윤명재; 이은영; 이은봉; 이윤종; 이태진; 함봉진; 송영욱
- Issue Date
- 2015
- Publisher
- 대한류마티스학회
- Keywords
- Systemic lupus erythematosus; Depression; Quality of life; Brain-derived neurotrophic factor; Vitamin D
- Citation
- 대한류마티스학회지, v.22, no.6, pp 346 - 355
- Pages
- 10
- Journal Title
- 대한류마티스학회지
- Volume
- 22
- Number
- 6
- Start Page
- 346
- End Page
- 355
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/11121
- ISSN
- 2093-940X
2233-4718
- Abstract
- The objective of this study is to examine the prevalence of depression and its related factors including quality of life, brain-derived neurotrophic factor (BDNF), and vitamin D in patients with systemic lupus erythematosus (SLE). Methods. Depression was assessed using the center for epidemiologic studies depression (CES-D) scale. Disease activity, disease-related organ damage, the EuroQol-5 dimensions (EQ-5D), sociodemographic features, and laboratory tests including serum vitamin D level were surveyed. Serum BDNF was measured using an enzyme-linked immunosorbent assay. Results. Depression was observed in 22.8% of 180 SLE patients (n=41). Patients with marital status of single/divorced/separated/widowed, a higher patient global assessment (PGA) score, and extreme pain/discomfort showed significant association with depression. The EQ-5D index showed negative correlation with CES-D score (r=−0.56, p<0.05). In each EQ-5D dimension, depression showed significant association with moderate to severe problems in self-care and usual activities, and extreme pain/discomfort. Serum BDNF levels were not associated with depression (p=0.75) but associated with SLE disease activity index (SLEDAI; r=−0.21, p<0.05). Serum vitamin D levels were not associated with depression (p=0.60) but showed negative correlation with SLEDAI (r=−0.23, p<0.05) and mean glucocorticoid dose over the previous 3 months (r=−0.21, p<0.05) after adjustment for use of vitamin D supplement. Conclusion. Depression was prevalent in patients with SLE and was associated with low quality of life, and a higher PGA but not with SLEDAI. Serum BDNF and vitamin D levels were not associated with depression but showed negative correlation with SLEDAI.
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