국소진행성 중위부 식도암의 동시항암화학 호흡동조 세기변조방사선치료의 포괄적인 임상고찰

Abstract

The standard treatment of locally advanced type of mid-esophageal cancer is concurrent chemoradiation ther-apy (CRT). We evaluated the feasibility of chemotherapy with adding docetaxel to the classical basic regimens of cisplatin plus 5-fluorouracil (5-FU) and radiotherapy up to 70.2 Gy using dose escalations for esophageal cancer. It was possible to escalate radiation treatment dose up to 70.2 Gy by the respiratory-gated in-tensity-modulated radiotherapy (gated-IMRT) based on the 4DCT-simulation, with improving target coverage and normal tissue (ex., lung, heart, and spinal cord) sparing. This study suggested that the definitive chemo-radio-therapy with docetaxel, cisplatin, and 5-fluorouracil (i.e., DCF-R) and gating IMRT is tolerable and active in pa-tients with locally advanced mid-esophageal cancer (AEC).