Position Statement: Drug Holiday in Osteoporosis Treatment with Bisphosphonates in South KoreaPosition Statement: Drug Holiday in Osteoporosis Treatment with Bisphosphonates in South Korea
- Other Titles
- Position Statement: Drug Holiday in Osteoporosis Treatment with Bisphosphonates in South Korea
- Authors
- 이승헌; 공현식; 김태희; 박시영; 신정호; 조선욱; 변동원
- Issue Date
- 2015
- Publisher
- 대한골대사학회
- Keywords
- Diphosphonates; Drug holiday; Fractures bone; Osteoporosis
- Citation
- 대한골대사학회지, v.22, no.4, pp.167 - 174
- Journal Title
- 대한골대사학회지
- Volume
- 22
- Number
- 4
- Start Page
- 167
- End Page
- 174
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/11158
- ISSN
- 2287-6375
- Abstract
- Bisphosphonates have been widely used in the treatment of osteoporosis with robust data from many placebo-controlled trials demonstrating its efficacy in fracture risk reduction over 3 to 5 years of treatment. Although bisphosphonates are generally safe and well tolerated, concerns have emerged about the adverse effects related to its longterm use, including osteonecrosis of the jaw and atypical femur fractures. Because bisphosphonates are incorporated into the skeleton and continue to exert an anti-resorptive effect for a period of time after the discontinuation of drugs, the concept of a “drug holiday” has emerged, whereby the risk of adverse effects might be decreased while the patient still benefits from anti-fracture efficacy. As randomized clinical trial evidence is not yet available on who may qualify for a drug holiday, there is considerable controversy regarding the selection of candidates for the drug holiday and monitoring during a drug holiday, both of which should be based on individual assessments of risk and benefit. This statement will provide suggestions for clinicians in South Korea on the identification of possible candidates and monitoring during a bisphosphonate drug holiday.
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Collections - College of Medicine > Department of Internal Medicine > 1. Journal Articles
- College of Medicine > Department of Obstetrics and Gynecology > 1. Journal Articles
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