LC-MS/MS 및 ICP를 이용한 당뇨환의 화학적 특성 분석
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 인정도 | - |
dc.contributor.author | 임대식 | - |
dc.contributor.author | 문승호 | - |
dc.contributor.author | 김원일 | - |
dc.date.accessioned | 2021-08-11T21:24:45Z | - |
dc.date.available | 2021-08-11T21:24:45Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1226-9174 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/11224 | - |
dc.description.abstract | Objectives: The primary aim of this study was to identify bioactive compounds in Dangnyo-hwan, a Korean herbal medicine, through instrumental analysis using LC-MS/MS and ICP, and investigate its potential use in diabetes treatment. Methods: The extract of Dangnyo-hwan has 12 medicinal herbs; these were compared with 18 marker substances selected from literature survey. Results: LC-MS/MS analysis could detect 9 of the 18 bioactive compounds: citruline, catalpol, berberine, ginsenoside Rb1, ginsenoside Rg1, oleanolic acid, β-sitosterol, mangiferin, and schizandrin. While harmful heavy metals such as As, Pb, Cd, Hg, Ni, and Cu were not present in high concentrations, Zn concentration was 4.2 mg in 100 g Dangnyo-hwan. Conclusions: Instrumental analysis such as LC-MS/MS and ICP was successfully used to identify bioactive compounds in Dangnyo-hwan. Detection of 9 bioactive substances and Zn from the herb medicine is a valuable finding, and suggests that Dangnyo-hwan is a candidate medicine for diabetes. Further investigations like in vitro assay, percent GPR 119 activity, and percent human DGAT-1 inhibition are underway. | - |
dc.language | 한국어 | - |
dc.language.iso | ko | - |
dc.publisher | 대한한방내과학회 | - |
dc.title | LC-MS/MS 및 ICP를 이용한 당뇨환의 화학적 특성 분석 | - |
dc.title.alternative | Characteristic Effects of Dangnyo-hwan for Diabetes Control Studied Using LC-MS/MS and ICP | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | 임대식 | - |
dc.identifier.bibliographicCitation | 대한한방내과학회지, v.36, no.3, pp.217 - 227 | - |
dc.relation.isPartOf | 대한한방내과학회지 | - |
dc.citation.title | 대한한방내과학회지 | - |
dc.citation.volume | 36 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 217 | - |
dc.citation.endPage | 227 | - |
dc.type.rims | ART | - |
dc.identifier.kciid | ART002039171 | - |
dc.description.journalClass | 2 | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | Dangnyo-hwan | - |
dc.subject.keywordAuthor | diabetes | - |
dc.subject.keywordAuthor | LC-MS/MS | - |
dc.subject.keywordAuthor | ICP | - |
dc.subject.keywordAuthor | marker substances | - |
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