LC-MS/MS 및 ICP를 이용한 당뇨환의 화학적 특성 분석Characteristic Effects of Dangnyo-hwan for Diabetes Control Studied Using LC-MS/MS and ICP
- Other Titles
- Characteristic Effects of Dangnyo-hwan for Diabetes Control Studied Using LC-MS/MS and ICP
- Authors
- 인정도; 임대식; 문승호; 김원일
- Issue Date
- 2015
- Publisher
- 대한한방내과학회
- Keywords
- Dangnyo-hwan; diabetes; LC-MS/MS; ICP; marker substances
- Citation
- 대한한방내과학회지, v.36, no.3, pp.217 - 227
- Journal Title
- 대한한방내과학회지
- Volume
- 36
- Number
- 3
- Start Page
- 217
- End Page
- 227
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/11224
- ISSN
- 1226-9174
- Abstract
- Objectives: The primary aim of this study was to identify bioactive compounds in Dangnyo-hwan, a Korean herbal medicine, through instrumental analysis using LC-MS/MS and ICP, and investigate its potential use in diabetes treatment.
Methods: The extract of Dangnyo-hwan has 12 medicinal herbs; these were compared with 18 marker substances selected from literature survey.
Results: LC-MS/MS analysis could detect 9 of the 18 bioactive compounds: citruline, catalpol, berberine, ginsenoside Rb1, ginsenoside Rg1, oleanolic acid, β-sitosterol, mangiferin, and schizandrin. While harmful heavy metals such as As, Pb, Cd, Hg, Ni, and Cu were not present in high concentrations, Zn concentration was 4.2 mg in 100 g Dangnyo-hwan.
Conclusions: Instrumental analysis such as LC-MS/MS and ICP was successfully used to identify bioactive compounds in Dangnyo-hwan. Detection of 9 bioactive substances and Zn from the herb medicine is a valuable finding, and suggests that Dangnyo-hwan is a candidate medicine for diabetes. Further investigations like in vitro assay, percent GPR 119 activity, and percent human DGAT-1 inhibition are underway.
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