Practical utility of insulin-like growth factor II mRNA-binding protein 3, glucose transporter 1, and epithelial membrane antigen for distinguishing malignant mesotheliomas from benign mesothelial proliferations
- Authors
- Chang, Sunhee; Oh, Mee-Hye; Ji, Sun-Young; Han, Joungho; Kim, Tae-Jung; Eom, Minseob; Kwon, Kun Young; Ha, Seung Yeon; Choi, Yoo Duk; Lee, Chang Hun; Lee, Yonghee; Jung, Soon-Hee
- Issue Date
- Dec-2014
- Publisher
- Blackwell Publishing Inc.
- Keywords
- epithelial membrane antigen; glucose transporter type 1; immunohistochemistry; insulin-like growth factor II mRNA-binding protein 3; mesothelioma
- Citation
- Pathology International, v.64, no.12, pp 607 - 612
- Pages
- 6
- Journal Title
- Pathology International
- Volume
- 64
- Number
- 12
- Start Page
- 607
- End Page
- 612
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/11673
- DOI
- 10.1111/pin.12216
- ISSN
- 1320-5463
1440-1827
- Abstract
- The differentiation of malignant mesotheliomas and benign mesothelial proliferations is crucial in determining patient care and prognosis. But, this distinction can be extremely difficult, particularly in small biopsies. Recently, insulin-like growth factor II mRNA-binding protein 3 (IMP3) and glucose transporter 1 (GLUT-1) have been reported as specific and sensitive markers in the distinction of mesotheliomas from benign mesothelial proliferations. The purpose of this study is to evaluate the utility of IMP3, GLUT-1, and epithelial membrane antigen (EMA) immunohistochemistry for distinguishing mesotheliomas from benign mesothelial proliferations. Immunoexpression of IMP3, GLUT-1, and EMA was evaluated in 88 malignant mesotheliomas, 35 adenomatoid tumors, and 20 benign lung tissues with reactive mesothelial cells. The sensitivity for IMP3, GLUT-1, and EMA was 37%, 21%, and 41%, respectively. The specificity for IMP3, GLUT-1, and EMA was 100%. When IMP3, GLUT1, and EMA combined, the sensitivity was 66% for IMP3/EMA staining, 53% for GLUT-1/EMA staining, and 45% for IMP3/GLUT-1. Use of IMP3 and EMA together is more helpful to distinguish malignant mesotheliomas from benign mesothelial proliferations than the use of IMP3 or EMA alone.
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