Management of viral hepatitis in liver transplant recipients
- Authors
- Jeong, Soung Won; Choi, YoungRok; Kim, Jin-Wook
- Issue Date
- Dec-2014
- Publisher
- 대한간학회
- Keywords
- Liver transplantation; Viral hepatitis; Recurrence; Management; Antiviral therapy
- Citation
- Clinical and Molecular Hepatology, v.20, no.4, pp 338 - 344
- Pages
- 7
- Journal Title
- Clinical and Molecular Hepatology
- Volume
- 20
- Number
- 4
- Start Page
- 338
- End Page
- 344
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/11690
- DOI
- 10.3350/cmh.2014.20.4.338
- ISSN
- 2287-2728
2287-285X
- Abstract
- Recurrence of viral hepatitis after liver transplantation (LT) can progress to graft failure and lead to a decrease in longterm survival. Recently, there have been remarkable improvement in the treatment of chronic hepatitis B (CHB) using potent antiviral agents. Combination of hepatitis B immunoglobulin and potent antiviral therapy has brought marked advances in the management of CHB for liver transplant recipients. Post-transplant antiviral therapy for hepatitis C virus infection is generally reserved for patients showing progressive disease. Acheiving a sustained virological response in patients with LT greatly ameliorates graft and overall survival, however this only occurs in 30% of transplant recipient using pegylated interferon and ribavirin (RBV). Direct acting antivirals such as protease inhibitors, polymerase or other non-structural proteins inhibitors are anticipated to establish the new standard of care for transplant recipients. In liver transplant recipients, hepatitis E virus infection is an uncommon disease. However, it can lead to chronic hepatitis and cirrhosis and may require retransplantation. Recently, 3-month course of RBV monotherapy has been reported as an effective treatment. This review focuses on the recent management and therapeutic approaches of viral hepatitis in liver transplant recipient.
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