Diagnostic and Therapeutic Approach for Acute Paraquat Intoxication
DC Field | Value | Language |
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dc.contributor.author | Gil, Hyo-Wook | - |
dc.contributor.author | Hong, Jung-Rak | - |
dc.contributor.author | Jang, Si-Hyong | - |
dc.contributor.author | Hong, Sae-Yong | - |
dc.date.accessioned | 2021-08-11T22:24:38Z | - |
dc.date.available | 2021-08-11T22:24:38Z | - |
dc.date.issued | 2014-11 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.issn | 1598-6357 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/11761 | - |
dc.description.abstract | Paraquat (PQ) has known negative human health effects, but continues to be commonly used worldwide as a herbicide. Our clinical data shows that the main prognostic factor is the time required to achieve a negative urine dithionite test. Patient survival is a 100% when the area affected by ground glass opacity is < 20% of the total lung volume on high-resolution computed tomography imaging 7 days post-PQ ingestion. The incidence of acute kidney injury is approximately 50%. The average serum creatinine level reaches its peak around 5 days post-ingestion, and usually normalizes within 3 weeks. We obtain two connecting lines from the highest PQ level for the survivors and the lowest PQ level among the non-survivors at a given time. Patients with a PQ level between these two lines are considered treatable. The following treatment modalities are recommended to preserve kidney function: 1) extracorporeal elimination, 2) intravenous antioxidant administration, 3) diuresis with a fluid, and 4) cytotoxic drugs. In conclusion, this review provides a general overview on the diagnostic procedure and treatment modality of acute PQ intoxication, while focusing on our clinical experience. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한의학회 | - |
dc.title | Diagnostic and Therapeutic Approach for Acute Paraquat Intoxication | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.3346/jkms.2014.29.11.1441 | - |
dc.identifier.scopusid | 2-s2.0-84964313930 | - |
dc.identifier.wosid | 000345321400001 | - |
dc.identifier.bibliographicCitation | Journal of Korean Medical Science, v.29, no.11, pp 1441 - 1449 | - |
dc.citation.title | Journal of Korean Medical Science | - |
dc.citation.volume | 29 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1441 | - |
dc.citation.endPage | 1449 | - |
dc.type.docType | Review | - |
dc.identifier.kciid | ART001928141 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | INDUCED OXIDATIVE STRESS | - |
dc.subject.keywordPlus | II CELLS | - |
dc.subject.keywordPlus | ANTIOXIDANT STATUS | - |
dc.subject.keywordPlus | HUMAN-DISEASE | - |
dc.subject.keywordPlus | IRON | - |
dc.subject.keywordPlus | GLUTATHIONE | - |
dc.subject.keywordPlus | LUNG | - |
dc.subject.keywordPlus | TOXICITY | - |
dc.subject.keywordPlus | INJURY | - |
dc.subject.keywordPlus | METHYLPREDNISOLONE | - |
dc.subject.keywordAuthor | Paraquat | - |
dc.subject.keywordAuthor | Reactive Oxygen Species | - |
dc.subject.keywordAuthor | Antioxidants | - |
dc.subject.keywordAuthor | Hemoperfusion | - |
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