Diagnostic and Therapeutic Approach for Acute Paraquat Intoxication
- Authors
- Gil, Hyo-Wook; Hong, Jung-Rak; Jang, Si-Hyong; Hong, Sae-Yong
- Issue Date
- Nov-2014
- Publisher
- 대한의학회
- Keywords
- Paraquat; Reactive Oxygen Species; Antioxidants; Hemoperfusion
- Citation
- Journal of Korean Medical Science, v.29, no.11, pp 1441 - 1449
- Pages
- 9
- Journal Title
- Journal of Korean Medical Science
- Volume
- 29
- Number
- 11
- Start Page
- 1441
- End Page
- 1449
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/11761
- DOI
- 10.3346/jkms.2014.29.11.1441
- ISSN
- 1011-8934
1598-6357
- Abstract
- Paraquat (PQ) has known negative human health effects, but continues to be commonly used worldwide as a herbicide. Our clinical data shows that the main prognostic factor is the time required to achieve a negative urine dithionite test. Patient survival is a 100% when the area affected by ground glass opacity is < 20% of the total lung volume on high-resolution computed tomography imaging 7 days post-PQ ingestion. The incidence of acute kidney injury is approximately 50%. The average serum creatinine level reaches its peak around 5 days post-ingestion, and usually normalizes within 3 weeks. We obtain two connecting lines from the highest PQ level for the survivors and the lowest PQ level among the non-survivors at a given time. Patients with a PQ level between these two lines are considered treatable. The following treatment modalities are recommended to preserve kidney function: 1) extracorporeal elimination, 2) intravenous antioxidant administration, 3) diuresis with a fluid, and 4) cytotoxic drugs. In conclusion, this review provides a general overview on the diagnostic procedure and treatment modality of acute PQ intoxication, while focusing on our clinical experience.
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Collections - College of Medicine > Department of Pathology > 1. Journal Articles
- College of Medicine > Department of Internal Medicine > 1. Journal Articles
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