Enantioselective One-Pot Synthesis of Ring-Fused Tetrahydroquinolines via Aerobic Oxidation and 1,5-Hydride Transfer/Cyclization Sequences
- Authors
- Suh, Chang Won; Kim, Dae Young
- Issue Date
- 17-Oct-2014
- Publisher
- American Chemical Society
- Keywords
- Tetrahydroquinolines; 1; 5-Hydride transfer; aymmetric catalysis
- Citation
- Organic Letters, v.16, no.20, pp 5374 - 5377
- Pages
- 4
- Journal Title
- Organic Letters
- Volume
- 16
- Number
- 20
- Start Page
- 5374
- End Page
- 5377
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/11773
- DOI
- 10.1021/ol502575f
- ISSN
- 1523-7060
1523-7052
- Abstract
- Enantioselective organocatalytic synthesis of tetrahydroquinolines has been achieved via an aerobic oxidation and a 1,5-hydride transfer/cyclization sequence. The feature of this research is a one-pot transformation of 3-arylprop-2-en-1-ol derivatives into tetrahydroquinolines using a Ru(VII)-catalyzed aerobic oxidation and highly efficient internal redox reactions. The synthetically useful ring-fused tetrahydroquinoline derivatives are obtained in moderate yields and high levels of enantioselectivity.
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Collections - College of Natural Sciences > Department of Chemistry > 1. Journal Articles
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