Carnosic acid inhibits TLR4-MyD88 signaling pathway in LPS-stimulated 3T3-L1 adipocytes
DC Field | Value | Language |
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dc.contributor.author | Park, Mi-Young | - |
dc.contributor.author | Mun, Seong Taek | - |
dc.date.accessioned | 2021-08-11T22:25:12Z | - |
dc.date.available | 2021-08-11T22:25:12Z | - |
dc.date.issued | 2014-10 | - |
dc.identifier.issn | 1976-1457 | - |
dc.identifier.issn | 2005-6168 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/11824 | - |
dc.description.abstract | BACKGROUND/OBJECTIVES: Carnosic acid (CA), found in rosemary (Rosemarinus officinalis) leaves, is known to exhibit anti-obesity and anti-inflammatory activities. However, whether its anti-inflammatory potency can contribute to the amelioration of obesity has not been elucidated. The aim of the current study was to investigate the effect of CA on Toll-like receptor 4 (TLR4) pathways in the presence of lipopolysaccharide (LPS) in 3T3-L1 adipocytes. MATERIALS/METHODS: 3T3-L1 adipocytes were treated with CA (0-20 mu M) for 1 h, followed by treatment with LPS for 30 min; mRNA expression of adipokines and protein expression of TLR4-related molecules were then measured. RESULTS: LPS-stimulated 3T3-L1 adipocytes showed elevated mRNA expression of tumor necrosis factor (TNE)-alpha, interleukin-6, and monocyte chemoattractant protein-1, and CA significantly inhibited the expression of these adipokine genes. LPS-induced up regulation of TLR4, myeloid differentiation factor 88, TNF receptor-associated factor 6, and nuclear factor-kappa B, as well as phosphorylated extracellular receptor-activated kinase were also suppressed by pre-treatment of 3T3-L1 adipocytes with CA. CONCLUSIONS: Results of this study suggest that CA directly inhibits TLR4-MyD88-dependent signaling pathways and decreases the inflammatory response in adipocytes. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 한국영양학회 | - |
dc.title | Carnosic acid inhibits TLR4-MyD88 signaling pathway in LPS-stimulated 3T3-L1 adipocytes | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.4162/nrp.2014.8.5.516 | - |
dc.identifier.scopusid | 2-s2.0-84908068386 | - |
dc.identifier.wosid | 000342526700005 | - |
dc.identifier.bibliographicCitation | Nutrition Research and Practice, v.8, no.5, pp 516 - 520 | - |
dc.citation.title | Nutrition Research and Practice | - |
dc.citation.volume | 8 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 516 | - |
dc.citation.endPage | 520 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001912325 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | TOLL-LIKE RECEPTORS | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | ROSMARINUS-OFFICINALIS | - |
dc.subject.keywordPlus | INNATE IMMUNITY | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | DIET | - |
dc.subject.keywordPlus | SUPPRESSES | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordAuthor | 3T3-L1 adipocytes | - |
dc.subject.keywordAuthor | carnosic acid | - |
dc.subject.keywordAuthor | inflammation | - |
dc.subject.keywordAuthor | toll-like receptor 4 | - |
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