Surface modification of porous polycaprolactone/biphasic calcium phosphate scaffolds for bone regeneration in rat calvaria defect
DC Field | Value | Language |
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dc.contributor.author | Kim, Ji-Hyun | - |
dc.contributor.author | Linh, Nguyen T. B. | - |
dc.contributor.author | Min, Young K. | - |
dc.contributor.author | Lee, Byong-Taek | - |
dc.date.accessioned | 2021-08-11T22:25:23Z | - |
dc.date.available | 2021-08-11T22:25:23Z | - |
dc.date.issued | 2014-10 | - |
dc.identifier.issn | 0885-3282 | - |
dc.identifier.issn | 1530-8022 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/11836 | - |
dc.description.abstract | In this study, polycaprolactone scaffolds fabricated by a salt-leaching process were loaded with biphasic calcium phosphate successfully to improve the osteoconductivity in bone regeneration. The surface of polycaprolactone/biphasic calcium phosphate scaffolds was aminolyzed by 1,6-hexamethylenediamine to introduce amino groups onto the surface, which was verified qualitatively by ninhyrin staining. Collagen was further immobilized on the aminolyzed porous polycaprolactone via N-ethyl-N-(3-dimethylaminopropy) carbodiimide hydrochloride/hydroxy-2,5-dioxopyrolidine-3-sulfonic acid sodium cross-linking. The pore size of polycaprolactone/biphasic calcium phosphate-collagen scaffolds was 200-300 mu m, which was suitable for bone in-growth. The X-ray photoelectron spectroscopy confirmed the coupling of collagen immobilized on the surface of polycaprolactone/biphasic calcium phosphate. In vitro results demonstrated that the spreading and viability of MC3T3-E1 cells were remarkably improved in the polycaprolactone/biphasic calcium phosphate-collagen scaffolds. The in vivo study was carried out by implanting the porous polycaprolactone, polycaprolactone/biphasic calcium phosphate, and polycaprolactone/biphasic calcium phosphate-collagen to the skulls of rats. Although the addition of biphasic calcium phosphate particles in the polycaprolactone scaffolds does not have a strong effect on the new bone formation, the immobilization of collagen on the polycaprolactone/biphasic calcium phosphate scaffolds significantly improved the bone regeneration even though the implantation time was short, 6 weeks. The present results provide more evidence that functionalizing polycaprolactone with biphasic calcium phosphate and collagen may be a feasible way to improve the osteoconduction in bone regeneration. | - |
dc.format.extent | 12 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | SAGE Publications | - |
dc.title | Surface modification of porous polycaprolactone/biphasic calcium phosphate scaffolds for bone regeneration in rat calvaria defect | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1177/0885328214539822 | - |
dc.identifier.scopusid | 2-s2.0-84907155409 | - |
dc.identifier.wosid | 000342807300013 | - |
dc.identifier.bibliographicCitation | Journal of Biomaterials Applications, v.29, no.4, pp 624 - 635 | - |
dc.citation.title | Journal of Biomaterials Applications | - |
dc.citation.volume | 29 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 624 | - |
dc.citation.endPage | 635 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | OSTEOGENIC DIFFERENTIATION | - |
dc.subject.keywordPlus | TISSUE | - |
dc.subject.keywordPlus | HYDROXYAPATITE | - |
dc.subject.keywordPlus | IMMOBILIZATION | - |
dc.subject.keywordPlus | BIOMATERIALS | - |
dc.subject.keywordPlus | COLLAGEN | - |
dc.subject.keywordPlus | FABRICATION | - |
dc.subject.keywordPlus | GLYCOSAMINOGLYCANS | - |
dc.subject.keywordPlus | FUNCTIONALIZATION | - |
dc.subject.keywordAuthor | Porous PCL | - |
dc.subject.keywordAuthor | BCP | - |
dc.subject.keywordAuthor | aminolysis | - |
dc.subject.keywordAuthor | surface modification | - |
dc.subject.keywordAuthor | collagen immobilization | - |
dc.subject.keywordAuthor | bone regeneration | - |
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