Short-term effects of topical cyclosporine A 0.05% (Restasis) in long-standing prosthetic eye wearers: a pilot study
DC Field | Value | Language |
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dc.contributor.author | Han, J. W. | - |
dc.contributor.author | Yoon, J. S. | - |
dc.contributor.author | Jang, S. Y. | - |
dc.date.accessioned | 2021-08-11T22:25:28Z | - |
dc.date.available | 2021-08-11T22:25:28Z | - |
dc.date.issued | 2014-10 | - |
dc.identifier.issn | 0950-222X | - |
dc.identifier.issn | 1476-5454 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/11841 | - |
dc.description.abstract | Purpose Long-standing prosthetic eye wearing induces ocular surface inflammation. We investigated the short-term effects of topical cyclosporine A 0.05% (Restasis) in patients with ocular discomfort resulting from long-standing prosthetic eye wearing. Methods This was a prospective, interventional case series. Patients who were unilateral prosthetic eye wearers over a period of 5 years were enrolled at a single institution from March to July 2013. The subjects were instructed to instill topical cyclosporine A 0.05% twice per day. Measurements were made pre-treatment and after 1 and 3 months of treatment. Outcome measures were the ocular symptom score, the lid margin abnormality score, the Schirmer test, and the tear meniscus amount, using Fourier-domain optical coherence tomography. Results In total, 20 consecutive patients (mean age: 60.1 years, 8 males, 12 females) were included. Ocular symptoms were improved after treatment for 1 month in all patients (ocular symptom score pre-treatment 76.83 vs 46.75 after treatment; P<0.001). There was no statistically significant difference in lid margin abnormality score or tear meniscus amount. The Schirmer test results were improved after treatment for 3 months (pre- and after treatment, 6.70 vs 11.40; P<0.001). Conclusions Topical cyclosporine A 0.05% showed a satisfactory effect in long-standing prosthetic eye wearers. Ocular symptoms were markedly relieved in all subjects after treatment for 1 month. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Nature Publishing Group | - |
dc.title | Short-term effects of topical cyclosporine A 0.05% (Restasis) in long-standing prosthetic eye wearers: a pilot study | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1038/eye.2014.174 | - |
dc.identifier.scopusid | 2-s2.0-84927675213 | - |
dc.identifier.wosid | 000343771100011 | - |
dc.identifier.bibliographicCitation | Eye, v.28, no.10, pp 1212 - 1217 | - |
dc.citation.title | Eye | - |
dc.citation.volume | 28 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1212 | - |
dc.citation.endPage | 1217 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Ophthalmology | - |
dc.relation.journalWebOfScienceCategory | Ophthalmology | - |
dc.subject.keywordPlus | MEIBOMIAN GLAND DYSFUNCTION | - |
dc.subject.keywordPlus | DRY-EYE | - |
dc.subject.keywordPlus | KERATOCONJUNCTIVITIS SICCA | - |
dc.subject.keywordPlus | OPHTHALMIC EMULSION | - |
dc.subject.keywordPlus | OCULAR PROSTHESIS | - |
dc.subject.keywordPlus | ARTIFICIAL EYES | - |
dc.subject.keywordPlus | TEAR CYTOKINE | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | CONJUNCTIVA | - |
dc.subject.keywordAuthor | 안과학 | - |
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