Short-term effects of topical cyclosporine A 0.05% (Restasis) in long-standing prosthetic eye wearers: a pilot study
- Authors
- Han, J. W.; Yoon, J. S.; Jang, S. Y.
- Issue Date
- Oct-2014
- Publisher
- Nature Publishing Group
- Keywords
- 안과학
- Citation
- Eye, v.28, no.10, pp 1212 - 1217
- Pages
- 6
- Journal Title
- Eye
- Volume
- 28
- Number
- 10
- Start Page
- 1212
- End Page
- 1217
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/11841
- DOI
- 10.1038/eye.2014.174
- ISSN
- 0950-222X
1476-5454
- Abstract
- Purpose Long-standing prosthetic eye wearing induces ocular surface inflammation. We investigated the short-term effects of topical cyclosporine A 0.05% (Restasis) in patients with ocular discomfort resulting from long-standing prosthetic eye wearing. Methods This was a prospective, interventional case series. Patients who were unilateral prosthetic eye wearers over a period of 5 years were enrolled at a single institution from March to July 2013. The subjects were instructed to instill topical cyclosporine A 0.05% twice per day. Measurements were made pre-treatment and after 1 and 3 months of treatment. Outcome measures were the ocular symptom score, the lid margin abnormality score, the Schirmer test, and the tear meniscus amount, using Fourier-domain optical coherence tomography. Results In total, 20 consecutive patients (mean age: 60.1 years, 8 males, 12 females) were included. Ocular symptoms were improved after treatment for 1 month in all patients (ocular symptom score pre-treatment 76.83 vs 46.75 after treatment; P<0.001). There was no statistically significant difference in lid margin abnormality score or tear meniscus amount. The Schirmer test results were improved after treatment for 3 months (pre- and after treatment, 6.70 vs 11.40; P<0.001). Conclusions Topical cyclosporine A 0.05% showed a satisfactory effect in long-standing prosthetic eye wearers. Ocular symptoms were markedly relieved in all subjects after treatment for 1 month.
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