Serum angiopoietin is associated with lung function in patients with asthma: a retrospective cohort study
DC Field | Value | Language |
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dc.contributor.author | Moon, Kuk-Young | - |
dc.contributor.author | Lee, PuReun-HaNeul | - |
dc.contributor.author | Park, Sung-Woo | - |
dc.contributor.author | Park, Choon-Sik | - |
dc.contributor.author | Jang, An-Soo | - |
dc.date.accessioned | 2021-08-11T22:25:46Z | - |
dc.date.available | 2021-08-11T22:25:46Z | - |
dc.date.issued | 2014-09-02 | - |
dc.identifier.issn | 1471-2466 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/11858 | - |
dc.description.abstract | Background: Angiopoietin-1 (Ang-1) is an essential mediator of angiogenesis that establishes vascular integrity, and angiopoietin-2 (Ang-2) acts as its natural inhibitor. We considered that angiopoietin might be important in bronchial asthma. Methods: In total, 35 patients with asthma and 20 healthy subjects were studied. Results: The serum Ang-1 levels were significantly elevated in patients with asthma compared to control subjects (293.9 +/- 13.8 pg/mL vs. 248.3 +/- 16.2 pg/mL, respectively, p = 0.04). The serum Ang-2 levels were not different between the two groups. The areas under the curve (AUC) for serum angiopoietins revealed that the serum level of Ang-1 (0.68) was more sensitive and specific than the serum Ang-2 level (0.55) for differentiating between patients with asthma and control subjects. The serum Ang-1/Ang-2 ratio was correlated with the FEV1/FVC ratio (r = -0.312, p = 0.02), while serum Ang-2 was correlated with body mass index. Conclusions: Our results indicate that the serum Ang-1 levels were higher in asthma patients compared with healthy subjects. As the Ang-1/Ang-2 ratio was related to lung function, the data suggest that serum angiopoietin is associated with lung function in patients with asthma. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | BioMed Central | - |
dc.title | Serum angiopoietin is associated with lung function in patients with asthma: a retrospective cohort study | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1186/1471-2466-14-143 | - |
dc.identifier.scopusid | 2-s2.0-84907386764 | - |
dc.identifier.wosid | 000341656300001 | - |
dc.identifier.bibliographicCitation | BMC Pulmonary Medicine, v.14 | - |
dc.citation.title | BMC Pulmonary Medicine | - |
dc.citation.volume | 14 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Respiratory System | - |
dc.relation.journalWebOfScienceCategory | Respiratory System | - |
dc.subject.keywordPlus | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject.keywordPlus | AIRWAY VASCULATURE | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | VASCULARITY | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | PROTECTS | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | SPUTUM | - |
dc.subject.keywordAuthor | Angiogenesis | - |
dc.subject.keywordAuthor | Angiopoietin-1 | - |
dc.subject.keywordAuthor | Angiopoietin-2 | - |
dc.subject.keywordAuthor | Asthma | - |
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