Serum angiopoietin is associated with lung function in patients with asthma: a retrospective cohort study
- Authors
- Moon, Kuk-Young; Lee, PuReun-HaNeul; Park, Sung-Woo; Park, Choon-Sik; Jang, An-Soo
- Issue Date
- 2-Sep-2014
- Publisher
- BioMed Central
- Keywords
- Angiogenesis; Angiopoietin-1; Angiopoietin-2; Asthma
- Citation
- BMC Pulmonary Medicine, v.14
- Journal Title
- BMC Pulmonary Medicine
- Volume
- 14
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/11858
- DOI
- 10.1186/1471-2466-14-143
- ISSN
- 1471-2466
- Abstract
- Background: Angiopoietin-1 (Ang-1) is an essential mediator of angiogenesis that establishes vascular integrity, and angiopoietin-2 (Ang-2) acts as its natural inhibitor. We considered that angiopoietin might be important in bronchial asthma. Methods: In total, 35 patients with asthma and 20 healthy subjects were studied. Results: The serum Ang-1 levels were significantly elevated in patients with asthma compared to control subjects (293.9 +/- 13.8 pg/mL vs. 248.3 +/- 16.2 pg/mL, respectively, p = 0.04). The serum Ang-2 levels were not different between the two groups. The areas under the curve (AUC) for serum angiopoietins revealed that the serum level of Ang-1 (0.68) was more sensitive and specific than the serum Ang-2 level (0.55) for differentiating between patients with asthma and control subjects. The serum Ang-1/Ang-2 ratio was correlated with the FEV1/FVC ratio (r = -0.312, p = 0.02), while serum Ang-2 was correlated with body mass index. Conclusions: Our results indicate that the serum Ang-1 levels were higher in asthma patients compared with healthy subjects. As the Ang-1/Ang-2 ratio was related to lung function, the data suggest that serum angiopoietin is associated with lung function in patients with asthma.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Internal Medicine > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.