Incretin levels 1 month after laparoscopic single anastomosis gastric bypass surgery in non-morbid obese type 2 diabetes patients
- Authors
- Kim, Myung Jin; Park, Hyeong Kyu; Byun, Dong Won; Suh, Kyo Il; Hur, Kyung Yul
- Issue Date
- Jul-2014
- Publisher
- Elsevier Taiwan
- Keywords
- gastric bypass incretin; metabolic surgery; type 2 diabetes mellitus
- Citation
- Asian Journal of Surgery, v.37, no.3, pp 130 - 137
- Pages
- 8
- Journal Title
- Asian Journal of Surgery
- Volume
- 37
- Number
- 3
- Start Page
- 130
- End Page
- 137
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/12054
- DOI
- 10.1016/j.asjsur.2013.09.008
- ISSN
- 1015-9584
0219-3108
- Abstract
- Purpose: Bariatric surgery is an efficient procedure for the remission of type 2 diabetes (T2DM) from morbid obesity. However, in Asian countries, the mean body mass index (BMI) of T2DM patients is about 25 kg/m(2). Various data on patients undergoing gastric bypass surgery suggest that the control of T2DM after surgery occurs rapidly. We hypothesized that even in nonobese patients with T2DM, the levels of incretin and insulin changed along with the improvement of T2DM as a consequence of the gastric bypass. Materials and methods: From March to December 2011, 12 nonobese patients (mean BMI; 26.2 kg/m(2)) with poorly-controlled [mean glycated hemoglobin (HbA1C); 9.5%] diabetes underwent gastric bypass surgery. Values related to diabetes, including incretin [gastric inhibitory peptide (GIP) and glucagon-like peptide-1 (GLP-1)] levels were measured before and 1 month after surgery. All values were measured in response to a 75 g oral glucose tolerance test (OGTT). Results: On average, the BMI decreased by 2.1 +/- 0.7 kg/m(2). Mean HbA1C level decreased by 1.6 +/- 2%. Oral glucose-stimulated insulin levels increased and GLP-1 levels also increased significantly. Oral glucose-stimulated GIP levels decreased sharply. Conclusion: Soon after gastric bypass in nonobese T2DM patients, control of T2DM is achieved. The incretin release after oral glucose is improved. This could be a consequence of changes of the enteroinsular axis, particularly in the incretins. Copyright (C) 2013, Asian Surgical Association. Published by Elsevier Taiwan LLC. All rights reserved.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of General Surgery > 1. Journal Articles
- College of Medicine > Department of Internal Medicine > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/12054)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.