Safety and efficacy of recombinant human erythropoietin treatment of non-motor symptoms in Parkinson's disease
- Authors
- Jang, Wooyoung; Park, Jinse; Shin, Kyung Jin; Kim, Joong-Seok; Kim, Ji Sun; Youn, Jinyoung; Cho, Jin Whan; Oh, Eungseok; Ahn, Jin Young; Oh, Ki-Wook; Kim, Hee-Tae
- Issue Date
- 15-Feb-2014
- Publisher
- Elsevier BV
- Keywords
- Erythropoietin; Non-motor symptoms; Parkinson's disease; PET; Safety; Efficacy
- Citation
- Journal of the Neurological Sciences, v.337, no.1-2, pp 47 - 54
- Pages
- 8
- Journal Title
- Journal of the Neurological Sciences
- Volume
- 337
- Number
- 1-2
- Start Page
- 47
- End Page
- 54
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/12421
- DOI
- 10.1016/j.jns.2013.11.015
- ISSN
- 0022-510X
1878-5883
- Abstract
- Background: Numerous animal studies and clinical trials have demonstrated that erythropoietin (EPO) has therapeutic effects in ischemic and degenerative diseases. However, few clinical trials have investigated the effect of EPO in Parkinson's disease (PD) patients. This study was an exploratory pilot study to investigate the effects of recombinant human EPO (rhEPO) on motor and non-motor symptoms (NMS) in PD patients. Methods: A total of 26 PD patients at the Hanyang University Hospital were enrolled in the study. The participants were randomly assigned to rhEPO and placebo groups. The rhEPO group was infused intravenously (40,000 IU each) twice a week for 5 weeks. Clinical improvement was estimated using the Unified Parkinson's Disease Rating Scale-III (UPDRS-III), the NMS Scale (NMSS) and the 39-Item Parkinson's Disease Questionnaire (PDQ-39). [F-18] N-(3-fluoropropyl)-2 beta-carbon ethoxy-3 beta-(4-iodophenyl) nortropane (FP-CIT) photon emission tomography (PET) scanning was performed on each participant at baseline and again after 12 months. Results: The rhEPO administration significantly improved the NMSS and PDQ-39 scores at 12 months. The UPDRS-III, which reflects motor function, did not change significantly after the rhEPO treatment. With the NMSS, the domains of cardiovascular autonomic function, sleep/fatigue, mood/cognition and attention/memory showed significant changes. None of the participants experienced any serious adverse effects. Discussion: We found that rhEPO had beneficial effects on NMS but not on motor function. Dopaminergic refractory NMS, such as cardiovascular autonomic dysfunction and cognition, showed improvement after the administration of rhEPO. Our results suggest that rhEPO might be a good candidate for the treatment of NMS in PD patients. (C) 2013 Published by Elsevier B.V.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Neurology > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.