The effects of running a 308 km ultra-marathon on cardiac markers
- Authors
- Kim, Young-Joo; Shin, Young-Oh; Lee, Jeong-Beom; Lee, Yoon-Hee; Shin, Kyung-A; Kim, Al-Chan; Goh, Choong-Won; Kim, Chul; Oh, Jae-Keun; Min, Young-Ki; Yang, Hun-Mo
- Issue Date
- 1-Jan-2014
- Publisher
- Taylor & Francis
- Keywords
- 308 km Ultra-marathon; cardiac markers; CK-MB; NT-proBNP
- Citation
- European Journal of Sport Science, v.14, pp S92 - S97
- Journal Title
- European Journal of Sport Science
- Volume
- 14
- Start Page
- S92
- End Page
- S97
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/12525
- DOI
- 10.1080/17461391.2011.654267
- ISSN
- 1746-1391
1536-7290
- Abstract
- The aim of this study was to investigate the expression of cardiac strain and damage in 18 male marathoners with average age of 52.8 +/- 5.0 years running at a 308 km ultra-marathon. Blood samples were collected at pre-race, 100 km, 200 km and 308 km check points for the analysis of cardiac muscle injury markers, creatine kinase (CK), creatine kinase-myocardial band (CK-MB), cardiac troponin I (cTnI) and cardiac muscle strain marker, N-terminal pro-brain natriuretic peptide (NT-proBNP). The CK levels increased 1127.2 +/- 507.9 IU/L, 5133.8 +/- 2492.7 IU/L and 4958.4 +/- 2087.9 IU/L at 100 km, 200 km and 308 km, respectively, compared to the pre-race levels. The CK-MB levels increased 20.2 +/- 11.2 ng/mL, 73.3 +/- 35.6 ng/mL and 68.6 +/- 42.6 ng/mL at 100, 200 and 308 km, respectively, compared to the pre-race levels. The CK-MB/CK ratio showed that the CK-MB mass index was within the normal range (<2.5%) at 100 km, 200 km and 308 km. The cTnI levels showed no significant difference in all check points. The NT-proBNP levels increased 146.55 +/- 92.7 pg/mL, 167.95 +/- 111.9 pg/mL and 241.23 +/- 121.2 pg/mL at 100, 200 and 308 km, respectively, compared to the pre-race levels. The normal CK-MB mass index (<5.0 ng/mL) and the absence of an increase in the cTnI levels during the 308 km ultra-marathon suggested that no myocardial injury despite an elevation in CK-MB. The increase in NT-proBNP levels probably resulted from continuous hemodynamic cardiac stress and represents a transient physiological myocardial protective response.
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