Differential Expression of E-Cadherin, beta-Catenin, and S100A4 in Intestinal Type and Nonintestinal Type Ampulla of Vater Cancers
- Authors
- Sung, Rohyun; Kang, Li; Han, Joung-Ho; Choi, Jae-Woon; Lee, Sang Hwa; Lee, Tae Hoon; Park, Sang-Heum; Kim, Hong Ja; Lee, Eaum Seok; Kim, Young Suk; Choi, Young Woo; Park, Seon Mee
- Issue Date
- Jan-2014
- Publisher
- 거트앤리버 발행위원회
- Keywords
- Ampullary adenocarcinoma; Intestinal type; Pancreatobiliary type; Epithelial-mesenchymal transition
- Citation
- Gut and Liver, v.8, no.1, pp 94 - 101
- Pages
- 8
- Journal Title
- Gut and Liver
- Volume
- 8
- Number
- 1
- Start Page
- 94
- End Page
- 101
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/12588
- DOI
- 10.5009/gnl.2014.8.1.94
- ISSN
- 1976-2283
2005-1212
- Abstract
- Background/Aims: Epithelial-mesenchymal transition (EMT)related proteins may exhibit differential expression in intestinal type or pancreatobiliary type ampulla of Vater carcinomas (AVCs). We evaluated the expression of E-cadherin, beta-catenin, and S100A4 in intestinal and nonintestinal type AVCs and analyzed their relationships with clinicopathological variables and survival. Methods: A clinicopathological review of 105 patients with AVCs and immunohistochemical staining for E-cadherin,beta-catenin, and S100A4 were performed. The association between clinicopathological parameters, histological type, and expression of EMT proteins and their effects on survival were analyzed. Results: Sixty-five intestinal type, 35 pancreatobiliary type, and five other types of AVCs were identified. The severity of EMT changes differed between the AVC types; membranous loss of E-cadherin and beta-catenin was observed in nonintestinal type tumors, whereas aberrant nonmembranous beta-catenin expression was observed in intestinal type tumors. EMT-related changes were more pronounced in the invasive tumor margin than in the tumor center, and these EMT-related changes were related to tumor aggressiveness. Among the clinicopathological parameters, a desmoplastic reaction was related to overall survival, and the reaction was more severe in nonintestinal type than in intestinal type AVCs. Conclusions: Dysregulation of E-cadherin, beta-cadherin, and S100A4 expression may play a role in the carcinogenesis and tumor progression of AVCs.
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Collections - College of Medicine > Department of Internal Medicine > 1. Journal Articles
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