Elevated Aurora Kinase A Protein Expression in Diabetic Skin Tissue
- Authors
- Cho, Moon Kyun; An, Je Min; Kim, Chul Han; Kang, Sang Gue
- Issue Date
- Jan-2014
- Publisher
- 대한성형외과학회
- Keywords
- Skin; Diabetes mellitus
- Citation
- Archives of Plastic Surgery, v.41, no.1, pp 35 - 39
- Pages
- 5
- Journal Title
- Archives of Plastic Surgery
- Volume
- 41
- Number
- 1
- Start Page
- 35
- End Page
- 39
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/12599
- DOI
- 10.5999/aps.2014.41.1.35
- ISSN
- 2234-6163
2234-6171
- Abstract
- Background Aurora kinase A (Aurora-A) plays an important role in the regulation of mitosis and cytokinesis. Dysregulated Aurora-A leads to mitotic faults and results in pathological conditions. No studies on Aurora-A expression in human diabetic skin tissue have been reported. In light of this, we explored the expression of Aurora-A in human diabetic skin tissue. Methods Aurora-A protein was evaluated by western blotting in 6 human diabetic skin tissue and 6 normal skin specimens. Results Increased expression of Aurora-A protein was detected in all diabetic skin tissue samples in both western blot analysis and immunohistochemical staining. However, in the case of the normal skin tissue, no bands of Aurora-A protein were detected in either the western blotting analysis or the immunohistochemical staining. Conclusions Thus far, there have been no studies on the expression of Aurora-A in diabetic skin tissue. However, we believe that oxidative DNA damage related to the expression of Aurora-A protein and Aurora-A could be involved inhuman diabetic skin tissue.
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- Appears in
Collections - College of Medicine > Department of Plastic Surgery > 1. Journal Articles
- College of Medicine > Department of Dermatology > 1. Journal Articles
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