Expression of Ezrin in Vagina Cells of Postmenopausal Rats after Dietary Administration of Omega-3 Fatty Acid FormulaExpression of Ezrin in Vagina Cells of Postmenopausal Rats after Dietary Administration of Omega-3 Fatty Acid Formula
- Other Titles
- Expression of Ezrin in Vagina Cells of Postmenopausal Rats after Dietary Administration of Omega-3 Fatty Acid Formula
- Authors
- 이해혁; 김태희; 박준식; 이아룸; 박용순; 변동원; 김민정; 임희숙
- Issue Date
- 2014
- Publisher
- 대한폐경학회
- Keywords
- Atrophic vaginitis; Diet; Fatty acids omega-3; Vagina
- Citation
- 대한폐경학회지, v.20, no.3, pp 97 - 103
- Pages
- 7
- Journal Title
- 대한폐경학회지
- Volume
- 20
- Number
- 3
- Start Page
- 97
- End Page
- 103
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/12664
- ISSN
- 2288-6478
2288-6761
- Abstract
- To see the effect of dietary administration of omega 3-fatty acid formula on the vaginal cells of postmenopausal rats.
Methods: Three-week-old female Wistar/ST rats were raised after one week of adjustment period. The rats were then dividedinto three groups, for three different kinds of diet; general diet, 1% omega-3 fatty acid diet, and 2% omega-3 fatty acid diet. Aftereight weeks of having assigned diet, after the oophorectomy, with the same diet previously they had Immunohistochemistry,Immunofluorescence, and Western Blot about ezrin, merlin were done.
Results: In immunohistochemistry, estrogen injection group revealed thicker and well differentiated features. In Immunofluorescence,Omega-3 fatty acid composition in diet did not effect expression of ezrin and merlin in rat vagina in estrogeninjection group, their vaginal epithelium showed full layers (from basal to apical layer). In Western Blot analysis, Omega-3 fatty acidcomposition in diet did not affect expression of ezrin and merlin in rat vagina estrogen presented significant impact on expressionof ezrin and merlin.
Conclusion: Although omega-3 fatty acid composition changed in diet, vaginal epithelial morphology unchanged. Estrogen dideffect on vagina cell, but omega-3 fatty acid did not effect on ezrin and merlin in vagina. (J Menopausal Med 2014;20:97-103)
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Collections - College of Medicine > Department of Internal Medicine > 1. Journal Articles
- College of Medicine > Department of Obstetrics and Gynecology > 1. Journal Articles
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