Proteomic analysis of domestic pig pancreas during development using two-dimensional electrophoresis and matrix-assisted laser desorption/ionization-time of flight mass spectrometry
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 안지예 | - |
dc.contributor.author | 김일용 | - |
dc.contributor.author | 오새진 | - |
dc.contributor.author | 황혜숙 | - |
dc.contributor.author | 이순신 | - |
dc.contributor.author | 김요나 | - |
dc.contributor.author | 신재훈 | - |
dc.contributor.author | 윤여성 | - |
dc.contributor.author | 성제경 | - |
dc.date.accessioned | 2021-08-11T23:46:17Z | - |
dc.date.available | 2021-08-11T23:46:17Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1738-6055 | - |
dc.identifier.issn | 2233-7660 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/12868 | - |
dc.description.abstract | Pig pancreas may be a therapeutic resource for human diabetic patients. However, this potential ishindered by a lack of knowledge of the molecular events of pig pancreas development. In this study, theembryonic day 60, neonate and 6-month protein profiles of pig pancreas were ascertained at using twodimensionalgel electrophoresis and matrix assisted laser desorption/ionization-time of flight massspectrometry. Twenty four proteins were differentially expressed during pig pancreas development. Among them, 12 spots increased and 7 spots decreased according to development. The expression of 5protein were highest at birth. Expression of digestive enzymes including trypsin, pancreatic triacylglycerollipase and pancreatic alpha-amylase was elevated in adults, whereas chymotrypsins were highly expressedin neonates. Proteins that were abundantly expressed during gestation were alpha-1-antitrypsin, alphafetoproteinand transferrins. Taken together, we found out that several proteins were significantly up- ordown- regulated from pig pancreas based on developmental stage. This study will provide basis forunderstanding development of pig pancreas. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 한국실험동물학회 | - |
dc.title | Proteomic analysis of domestic pig pancreas during development using two-dimensional electrophoresis and matrix-assisted laser desorption/ionization-time of flight mass spectrometry | - |
dc.title.alternative | Proteomic analysis of domestic pig pancreas during development using two-dimensional electrophoresis and matrix-assisted laser desorption/ionization-time of flight mass spectrometry | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.bibliographicCitation | Laboratory Animal Research, v.30, no.2, pp 45 - 53 | - |
dc.citation.title | Laboratory Animal Research | - |
dc.citation.volume | 30 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 45 | - |
dc.citation.endPage | 53 | - |
dc.identifier.kciid | ART001890170 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | Domestic pig | - |
dc.subject.keywordAuthor | pancreas | - |
dc.subject.keywordAuthor | development | - |
dc.subject.keywordAuthor | 2-DE proteomics | - |
dc.subject.keywordAuthor | MALDI-TOF | - |
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