알츠하이머병 뇌척수액 생물표지자 양성을 보인로고페닉진행실어증

Abstract

Primary progressive aphasia (PPA) is classified into agrammatic, semantic, and logopenic variants, but differentialdiagnosis is often challenging. There is accumulating evidence that the neuropathology of logopenic PPA is distinct fromthat of the other types. We report herein a woman with logopenic PPA who was diagnosed by clinical, neuropsychological,and radiologic data during 2 years of follow-up. Interestingly, her cerebrospinal fluid biomarkers were found to besimilar to those found in Alzheimer’s disease, with a decreased concentration of Aβ42 and an increased concentration ofpTau181 (tTau).