Suppression of TRIF-dependent signaling pathway of toll-like receptors by (E)-1-(2-(2-nitrovinyl)phenyl)pyrrolidine
- Authors
- Gu, Gyo-Jeong; Eom, Sang-Hoon; Suh, Chang Won; Koh, Kwang Oh; Kim, Dae Young; Youn, Hyung-Sun
- Issue Date
- 5-Dec-2013
- Publisher
- Elsevier BV
- Keywords
- Toll-like receptor; Lipopolysaccharide; Polyinosinic-polycytidylic acid; Interferon regulatory factor 3; (E)-1-(2-(2-nitrovinyl)phenyl)pyrrolidine
- Citation
- European Journal of Pharmacology, v.721, no.1-3, pp 109 - 115
- Pages
- 7
- Journal Title
- European Journal of Pharmacology
- Volume
- 721
- Number
- 1-3
- Start Page
- 109
- End Page
- 115
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/13053
- DOI
- 10.1016/j.ejphar.2013.09.045
- ISSN
- 0014-2999
1879-0712
- Abstract
- Toll-like receptors (TLRs) play an important role in the recognition of microbial pathogens and induce innate immune responses. The recognition of microbial components by TLRs triggers the activation of myeloid differential factor 88 (MyD88)- and toll-interleukin-1 receptor domain containing adapter inducing interferon-beta (TRIF)-dependent downstream signaling pathways. Previously, we synthesized (E)-1-(2-(2-nitrovinyl)phenyl)pyrrolidine (NVPP), which contains a nitrovinyl-phenyl and pyrrolidine. To evaluate the therapeutic potential of NVPP, its effect on signal transduction via the TRIF-dependent pathway of TLRs induced by lipopolysaccharide ([PS) or polyinosinic-polycytidylic acid (poly[I:C]) was examined. NVPP inhibited [PS or poly[I:C]-induced activation of nuclear factor-kappa B (NF-kappa B) and interferon regulatory factor 3 (IRF3), and the phosphorylalion of IRF3, as well as inhibiting the activation of interferon inducible genes such as interferon inducible protein-10 (IP-10). These results suggest that NVPP can modulate TRIP-dependent signaling pathways of TLRs, potentially resulting in effective therapeutics for chronic inflammatory diseases. (C) 2013 Elsevier B.V. All rights reserved.
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Collections - College of Medical Sciences > Department of Biomedical Laboratory Science > 1. Journal Articles
- College of Natural Sciences > Department of Chemistry > 1. Journal Articles
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