Fenobam promoted the neuroprotective effect of PEP-1-FK506BP following oxidative stress by increasing its transduction efficiency
DC Field | Value | Language |
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dc.contributor.author | Ahn, Eun Hee | - |
dc.contributor.author | Kim, Dae Won | - |
dc.contributor.author | Shin, Min Jea | - |
dc.contributor.author | Jo, Hyo Sang | - |
dc.contributor.author | Eom, Seon Ae | - |
dc.contributor.author | Kim, Duk-Soo | - |
dc.contributor.author | Park, Eun Young | - |
dc.contributor.author | Park, Jong Hoon | - |
dc.contributor.author | Cho, Sung-Woo | - |
dc.contributor.author | Park, Jinseu | - |
dc.contributor.author | Eum, Won Sik | - |
dc.contributor.author | Son, Ora | - |
dc.contributor.author | Hwang, Hyun Sook | - |
dc.contributor.author | Choi, Soo Young | - |
dc.date.accessioned | 2021-08-12T00:44:10Z | - |
dc.date.available | 2021-08-12T00:44:10Z | - |
dc.date.issued | 2013-11-30 | - |
dc.identifier.issn | 1976-6696 | - |
dc.identifier.issn | 1976-670X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/13202 | - |
dc.description.abstract | We examined the ways in which fenobam could promote not only the transduction of PEP-1-FK506BP into cells and tissues but also the neuroprotective effect of PEP-1-FK506BP against ischemic damage. Fenobam strongly enhanced the protective effect of PEP-1-FK506BP against H2O2-induced toxicity and DNA fragmentation in C6 cells. In addition, combinational treatment of fenobam with PEP-1-FK506BP significantly inhibited the activation of Akt and MAPK induced by H2O2, compared to treatment with PEP-1-FK506BP alone. Interestingly, our results showed that fenobam significantly increased the transduction of PEP-1-FK506BP into both C6 cells and the hippocampus of gerbil brains. Subsequently, a transient ischemic gerbil model study demonstrated that fenobam pretreatment led to the increased neuroprotection of PEP-1-FK506BP in the CA1 region of the hippocampus. Therefore, these results suggest that fenobam can be a useful agent to enhance the transduction of therapeutic PEP-1-fusion proteins into cells and tissues, thereby promoting their neuroprotective effects. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 생화학분자생물학회 | - |
dc.title | Fenobam promoted the neuroprotective effect of PEP-1-FK506BP following oxidative stress by increasing its transduction efficiency | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.5483/BMBRep.2013.46.11.080 | - |
dc.identifier.scopusid | 2-s2.0-84890219506 | - |
dc.identifier.wosid | 000328275200008 | - |
dc.identifier.bibliographicCitation | BMB Reports, v.46, no.11, pp 561 - 566 | - |
dc.citation.title | BMB Reports | - |
dc.citation.volume | 46 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 561 | - |
dc.citation.endPage | 566 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001820152 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | METABOTROPIC GLUTAMATE RECEPTORS | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | KINASE | - |
dc.subject.keywordPlus | POTENT | - |
dc.subject.keywordPlus | FKBP12 | - |
dc.subject.keywordPlus | CELL | - |
dc.subject.keywordAuthor | Fenobam | - |
dc.subject.keywordAuthor | Ischemic damage | - |
dc.subject.keywordAuthor | Neuroprotection | - |
dc.subject.keywordAuthor | PEP-1-FK506BP | - |
dc.subject.keywordAuthor | Protein transduction domains | - |
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