Associations of serum fetuin-A levels with insulin resistance and vascular complications in patients with type 2 diabetes
DC Field | Value | Language |
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dc.contributor.author | Jung, Chan-Hee | - |
dc.contributor.author | Kim, Bo-Yeon | - |
dc.contributor.author | Kim, Chul-Hee | - |
dc.contributor.author | Kang, Sung-Koo | - |
dc.contributor.author | Jung, Sang-Hee | - |
dc.contributor.author | Mok, Ji-Oh | - |
dc.date.accessioned | 2021-08-12T00:47:03Z | - |
dc.date.available | 2021-08-12T00:47:03Z | - |
dc.date.issued | 2013-09 | - |
dc.identifier.issn | 1479-1641 | - |
dc.identifier.issn | 1752-8984 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/13423 | - |
dc.description.abstract | Objective: We examined the relationship between serum fetuin-A, insulin resistance (IR), metabolic syndrome (MS) and vascular complications including cardiac autonomic neuropathy (CAN) in patients with type 2 diabetes mellitus (T2DM). Methods: A total of 172 T2DM patients were recruited and evaluated for diabetic microangiopathies (nephropathy, retinopathy and peripheral neuropathy) including CAN. Serum fetuin-A levels were measured by enzyme-linked immunosorbent assay (ELISA), and the IR was assessed by the index of homeostasis model [homeostasis model assessment-insulin resistance (HOMA-IR)]. Atherosclerotic burden was assessed by ankle-brachial index (ABI) and brachial-ankle pulse wave velocity (baPWV). Results: Serum fetuin-A levels showed significant positive correlations with HOMA-IR (r = 0.196, p = 0.022), and the mean levels of HOMA-IR were significantly increased progressively across fetuin-A tertiles (p for trend = 0.044). Serum fetuin-A showed significant positive correlations with baPWV, systolic blood pressure (BP), total cholesterol, triglycerides, serum fasting c-peptide and negative correlations with ABI. Serum fetuin-A levels were also negatively correlated with serum adiponectin and positively correlated with serum tumour necrosis factor- (TNF-). The mean levels of serum fetuin-A were not significantly different according to the presence of each microangiopathies including CAN. Also, the mean levels of serum fetuin-A were not different between patients with MS and without MS. Conclusions: This present study showed that levels of serum fetuin-A are significantly associated with IR and arterial stiffness assessed by baPWV, while there are no associations with each microangiopathies in patients with T2DM. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | SAGE Publications | - |
dc.title | Associations of serum fetuin-A levels with insulin resistance and vascular complications in patients with type 2 diabetes | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1177/1479164113490766 | - |
dc.identifier.scopusid | 2-s2.0-84882368793 | - |
dc.identifier.wosid | 000323113600009 | - |
dc.identifier.bibliographicCitation | Diabetes and Vascular Disease Research, v.10, no.5, pp 459 - 467 | - |
dc.citation.title | Diabetes and Vascular Disease Research | - |
dc.citation.volume | 10 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 459 | - |
dc.citation.endPage | 467 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Peripheral Vascular Disease | - |
dc.subject.keywordPlus | MELLITUS | - |
dc.subject.keywordPlus | HEART | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | INHIBITOR | - |
dc.subject.keywordPlus | STIFFNESS | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | DIALYSIS | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordAuthor | Fetuin-A | - |
dc.subject.keywordAuthor | insulin resistance | - |
dc.subject.keywordAuthor | metabolic syndrome | - |
dc.subject.keywordAuthor | microangiopathies | - |
dc.subject.keywordAuthor | type 2 diabetes mellitus | - |
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