Associations of serum fetuin-A levels with insulin resistance and vascular complications in patients with type 2 diabetes
- Authors
- Jung, Chan-Hee; Kim, Bo-Yeon; Kim, Chul-Hee; Kang, Sung-Koo; Jung, Sang-Hee; Mok, Ji-Oh
- Issue Date
- Sep-2013
- Publisher
- SAGE Publications
- Keywords
- Fetuin-A; insulin resistance; metabolic syndrome; microangiopathies; type 2 diabetes mellitus
- Citation
- Diabetes and Vascular Disease Research, v.10, no.5, pp 459 - 467
- Pages
- 9
- Journal Title
- Diabetes and Vascular Disease Research
- Volume
- 10
- Number
- 5
- Start Page
- 459
- End Page
- 467
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/13423
- DOI
- 10.1177/1479164113490766
- ISSN
- 1479-1641
1752-8984
- Abstract
- Objective: We examined the relationship between serum fetuin-A, insulin resistance (IR), metabolic syndrome (MS) and vascular complications including cardiac autonomic neuropathy (CAN) in patients with type 2 diabetes mellitus (T2DM). Methods: A total of 172 T2DM patients were recruited and evaluated for diabetic microangiopathies (nephropathy, retinopathy and peripheral neuropathy) including CAN. Serum fetuin-A levels were measured by enzyme-linked immunosorbent assay (ELISA), and the IR was assessed by the index of homeostasis model [homeostasis model assessment-insulin resistance (HOMA-IR)]. Atherosclerotic burden was assessed by ankle-brachial index (ABI) and brachial-ankle pulse wave velocity (baPWV). Results: Serum fetuin-A levels showed significant positive correlations with HOMA-IR (r = 0.196, p = 0.022), and the mean levels of HOMA-IR were significantly increased progressively across fetuin-A tertiles (p for trend = 0.044). Serum fetuin-A showed significant positive correlations with baPWV, systolic blood pressure (BP), total cholesterol, triglycerides, serum fasting c-peptide and negative correlations with ABI. Serum fetuin-A levels were also negatively correlated with serum adiponectin and positively correlated with serum tumour necrosis factor- (TNF-). The mean levels of serum fetuin-A were not significantly different according to the presence of each microangiopathies including CAN. Also, the mean levels of serum fetuin-A were not different between patients with MS and without MS. Conclusions: This present study showed that levels of serum fetuin-A are significantly associated with IR and arterial stiffness assessed by baPWV, while there are no associations with each microangiopathies in patients with T2DM.
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Collections - College of Medicine > Department of Internal Medicine > 1. Journal Articles
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