Evaluation of an Antimicrobial Silver Foam Dressing
- Authors
- Park, Jun Kyu; Lee, Jong Hoon; Kwak, Jeong Ja; Shin, Hee Bong; Jung, Hae Won; Bae, Sang Won; Yeo, Eui Dong; Lee, Young Koo; Yang, Seong Seok
- Issue Date
- Jun-2013
- Publisher
- H M P Communications
- Keywords
- nanosilver; vacuum-assisted closure; MRSA; rat
- Citation
- Wounds, v.25, no.6, pp 153 - 159
- Pages
- 7
- Journal Title
- Wounds
- Volume
- 25
- Number
- 6
- Start Page
- 153
- End Page
- 159
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/13646
- ISSN
- 1044-7946
1943-2704
- Abstract
- CuraVAC Ag, a product that delivers negative pressure wound therapy through a polyurethane foam dressing, contains silver nanoparticles, which, when moistened with water, release silver ions onto a wound surface. The in vitro antimicrobial action of silver can destroy both gram-positive and gram-negative bacteria, as well as methicillin-resistant Staphylococcus aureus (MRSA). The purpose of this study was to assess the efficacy and in vivo outcomes of using the product. Methods. Thirty-six female Sprague-Dawley white rats, 8-weeks old and 250 g - 300 g in weight, were used. The experimental product was prepared using a vacuum-assisted closure (VAC) kit and coating it using the silver nanoparticles. For the control group, a 10% povidone-iodine solution was applied. Results. All groups showed decreases in wound area over time, in the order CuraVAC Ag (group A) > CuraVAC (group B) > control (group C). On the third, fifth, and seventh days, wound healing efficacy scores increased in both group A and group C. Groups A and B showed more rapid decreases than group C in bacterial culture from wounds. Conclusion. CuraVAC Ag may be useful for treatment of wounds infected with bacteria.
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- Appears in
Collections - College of Medicine > Department of Orthopedic Surgery > 1. Journal Articles
- College of Medicine > Department of Clinical Pathology > 1. Journal Articles
- College of Medicine > Department of Pathology > 1. Journal Articles
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