KIM-1 expression predicts renal outcomes in IgA nephropathy
DC Field | Value | Language |
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dc.contributor.author | Kwon, Soon Hyo | - |
dc.contributor.author | Park, Moo Yong | - |
dc.contributor.author | Jeon, Jin Seok | - |
dc.contributor.author | Noh, Hyunjin | - |
dc.contributor.author | Choi, Soo Jeong | - |
dc.contributor.author | Kim, Jin Kuk | - |
dc.contributor.author | Hwang, Seung Duk | - |
dc.contributor.author | Jin, So Young | - |
dc.contributor.author | Han, Dong Cheol | - |
dc.date.accessioned | 2021-08-12T01:14:56Z | - |
dc.date.available | 2021-08-12T01:14:56Z | - |
dc.date.issued | 2013-06 | - |
dc.identifier.issn | 1342-1751 | - |
dc.identifier.issn | 1437-7799 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/13680 | - |
dc.description.abstract | Kidney injury molecule-1 (KIM-1) is a sensitive biomarker for proximal tubular injury. Recently, a few studies have shown that urinary KIM-1 has clinical implications in IgA nephropathy (IgAN). We performed this study to determine whether tissue KIM-1 has clinical implications for predicting long-term outcome and whether urinary KIM-1 is correlated with tissue KIM-1 and kidney injury in IgAN patients. We assessed the prognostic prediction capability of tissue KIM-1 expression in 69 adult patients with IgAN retrospectively. Renal biopsies from all patients were scored by a pathologist who was blinded to the clinical data for the pathologic variables. The primary outcome was the composite of a 50 % reduction in eGFR or end-stage renal disease. Tissue KIM-1 expression was assessed semiquantitatively by counting the stained tubules per 100x power field; 0 tubule indicates grade 0; 1-5 tubules, grade 1; 6-10 tubules, grade 2; and more than 10 tubules, grade 3. Comparing urinary KIM-1 and tissue KIM-1 expression, 50 consecutive IgAN patients were prospectively enrolled to measure urinary KIM-1 levels and examine their biopsy specimens by KIM-1 immunohistochemistry. Univariate analysis showed that tissue KIM-1 expression was associated with the renal outcome in IgAN. Multivariate regression analysis, as the relationship of tissue KIM-1 with prognosis, was consistent. Proteinuria at biopsy and tissue KIM-1 grade 3 were shown to have a prognostic value. The concentration of urinary KIM-1/Cr in patients with IgAN was significantly higher than that in the normal controls. Tissue KIM-1 expression is an independent predictor of adverse renal outcomes in IgA nephropathy patients. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Springer Verlag | - |
dc.title | KIM-1 expression predicts renal outcomes in IgA nephropathy | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1007/s10157-012-0707-2 | - |
dc.identifier.wosid | 000320450100006 | - |
dc.identifier.bibliographicCitation | Clinical and Experimental Nephrology, v.17, no.3, pp 359 - 364 | - |
dc.citation.title | Clinical and Experimental Nephrology | - |
dc.citation.volume | 17 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 359 | - |
dc.citation.endPage | 364 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Urology & Nephrology | - |
dc.relation.journalWebOfScienceCategory | Urology & Nephrology | - |
dc.subject.keywordPlus | KIDNEY INJURY MOLECULE-1 | - |
dc.subject.keywordPlus | CLINICOPATHOLOGICAL CORRELATIONS | - |
dc.subject.keywordPlus | OXFORD CLASSIFICATION | - |
dc.subject.keywordPlus | URINARY BIOMARKER | - |
dc.subject.keywordPlus | GLOMERULONEPHRITIS | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordAuthor | Biomarker | - |
dc.subject.keywordAuthor | IgA nephropathy | - |
dc.subject.keywordAuthor | Kidney injury molecule-1(KIM-1) | - |
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