KIM-1 expression predicts renal outcomes in IgA nephropathy
- Authors
- Kwon, Soon Hyo; Park, Moo Yong; Jeon, Jin Seok; Noh, Hyunjin; Choi, Soo Jeong; Kim, Jin Kuk; Hwang, Seung Duk; Jin, So Young; Han, Dong Cheol
- Issue Date
- Jun-2013
- Publisher
- Springer Verlag
- Keywords
- Biomarker; IgA nephropathy; Kidney injury molecule-1(KIM-1)
- Citation
- Clinical and Experimental Nephrology, v.17, no.3, pp 359 - 364
- Pages
- 6
- Journal Title
- Clinical and Experimental Nephrology
- Volume
- 17
- Number
- 3
- Start Page
- 359
- End Page
- 364
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/13680
- DOI
- 10.1007/s10157-012-0707-2
- ISSN
- 1342-1751
1437-7799
- Abstract
- Kidney injury molecule-1 (KIM-1) is a sensitive biomarker for proximal tubular injury. Recently, a few studies have shown that urinary KIM-1 has clinical implications in IgA nephropathy (IgAN). We performed this study to determine whether tissue KIM-1 has clinical implications for predicting long-term outcome and whether urinary KIM-1 is correlated with tissue KIM-1 and kidney injury in IgAN patients. We assessed the prognostic prediction capability of tissue KIM-1 expression in 69 adult patients with IgAN retrospectively. Renal biopsies from all patients were scored by a pathologist who was blinded to the clinical data for the pathologic variables. The primary outcome was the composite of a 50 % reduction in eGFR or end-stage renal disease. Tissue KIM-1 expression was assessed semiquantitatively by counting the stained tubules per 100x power field; 0 tubule indicates grade 0; 1-5 tubules, grade 1; 6-10 tubules, grade 2; and more than 10 tubules, grade 3. Comparing urinary KIM-1 and tissue KIM-1 expression, 50 consecutive IgAN patients were prospectively enrolled to measure urinary KIM-1 levels and examine their biopsy specimens by KIM-1 immunohistochemistry. Univariate analysis showed that tissue KIM-1 expression was associated with the renal outcome in IgAN. Multivariate regression analysis, as the relationship of tissue KIM-1 with prognosis, was consistent. Proteinuria at biopsy and tissue KIM-1 grade 3 were shown to have a prognostic value. The concentration of urinary KIM-1/Cr in patients with IgAN was significantly higher than that in the normal controls. Tissue KIM-1 expression is an independent predictor of adverse renal outcomes in IgA nephropathy patients.
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Collections - College of Medicine > Department of Pathology > 1. Journal Articles
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