Correlation between serum 25-hydroxyvitamin D levels and methicillin - resistant Staphylococcus aureus skin colonization in atopic dermatitis
- Authors
- Min, Taek Ki; Yang, Hyeon Jong; Lee, Hae Won; Pyun, Bok Yang
- Issue Date
- Jun-2013
- Publisher
- 대한 소아알레르기 호흡기학회
- Keywords
- Vitamin D; Methicillin-resistant Staphylococcus aureus; Atopic dermatitis
- Citation
- Allergy Asthma & Respiratory Diseases, v.1, no.2, pp 138 - 143
- Pages
- 6
- Journal Title
- Allergy Asthma & Respiratory Diseases
- Volume
- 1
- Number
- 2
- Start Page
- 138
- End Page
- 143
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/13684
- DOI
- 10.4168/aard.2013.1.2.138
- ISSN
- 2288-0402
2288-0410
- Abstract
- Purpose: Bacterial infection with Staphylococcus aureus is a common complication of atopic dermatitis (AD) and involved in the worsening of this disease. Recent studies have revealed an increasing prevalence of community-associated methicillin-resistant S. aureus (MRSA) among patients with AD and the role of vitamin D in the immunopathogenesis of AD. We carried out a study to see whether levels of vitamin D correlate with MRSA skin colonization in AD. Methods: Total 60 patients with AD aged between 3 months and 6 years old were enrolled. We measured disease severity using the Scoring Atopic Dermatitis (SCORAD) index, serum levels of 25-hydroxyvitamin D (25(OH) D), total immunoglobulin E levels, eosinophil cationic protein and bacterial colonization by skin swab and culture method. Results: S. aureus was cultured in 20 patients of the total (33.3%). MRSA was comprised 35% of the S. aureus- positive group. SCORAD value was significantly higher in S. aureus- positive group. Serum levels (mean +/- standard deviation) of 25( OH) D were lower in MRSA group (22.6 +/- 11.5 ng/mL) compared with those of methicillin- sensitive S. aureus group (31.3 +/- 10.2 ng/mL) or S. aureus negative group (34.3 +/- 15.8 ng/mL). But there was no statistically significant difference. Conclusion: Our study shows that the serum levels of 25(OH) D were lower in MRSA group. But there was no statistically significant difference. Therefore further studies including large numbers of cases are necessary.
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Collections - College of Medicine > Department of Pediatrics > 1. Journal Articles
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