Hepatoprotective effects of reynosin against thioacetamide-induced apoptosis in primary hepatocytes and mouse liver
DC Field | Value | Language |
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dc.contributor.author | Lim, Soohyun | - |
dc.contributor.author | Lee, Sung-Jin | - |
dc.contributor.author | Nam, Kung-Woo | - |
dc.contributor.author | Kim, Kyeong Ho | - |
dc.contributor.author | Mar, Woongchon | - |
dc.date.accessioned | 2021-08-12T01:18:27Z | - |
dc.date.available | 2021-08-12T01:18:27Z | - |
dc.date.issued | 2013-04 | - |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.issn | 1976-3786 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/13820 | - |
dc.description.abstract | The aim of this study was to identify the hepatoprotective effects of reynosin, sesquiterpenes from the leaves of Laurus nobilis, against thioacetamide (TAA)-induced apoptosis in primary hepatocyte cultures and an in vivo mouse model. Rat hepatocytes were isolated and pretreated with 0.13, 0.64, or 3.22 mu M reynosin and then exposed to 100 mM TAA. Reynosin treatment significantly inhibited TAA-induced apoptosis and hepatocellular DNA damage in primary rat hepatocytes. We observed an increase in levels of antiapoptotic Bcl-2, Bcl-XL mRNA and a decrease in levels of proapoptotic Bax mRNA following reynosin treatment of hepatocytes. Apoptosis in BALB/c mice was induced with intra-peritoneal injection of 200 mg/kg TAA for 2 weeks every other day. Then reynosin (5 mg/kg) and TAA were intragastrically given for 3 weeks every other day. Aspartate aminotransferase and alanine aminotransferase levels in the blood of mice were decreased in the reynosin administration group. Bcl-2 and Bcl-XL mRNA levels were increased, and the Bax mRNA level was decreased in reynosin-treated mice. Thus, reynosin inhibited TAA-induced apoptosis in primary hepatocytes and an in vivo mouse model. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한약학회 | - |
dc.title | Hepatoprotective effects of reynosin against thioacetamide-induced apoptosis in primary hepatocytes and mouse liver | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.1007/s12272-013-0039-0 | - |
dc.identifier.wosid | 000317969800012 | - |
dc.identifier.bibliographicCitation | Archives of Pharmacal Research, v.36, no.4, pp 485 - 494 | - |
dc.citation.title | Archives of Pharmacal Research | - |
dc.citation.volume | 36 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 485 | - |
dc.citation.endPage | 494 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001901885 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | SESQUITERPENE LACTONES | - |
dc.subject.keywordPlus | CARBON-TETRACHLORIDE | - |
dc.subject.keywordPlus | LAURUS-NOBILIS | - |
dc.subject.keywordPlus | NITRIC-OXIDE | - |
dc.subject.keywordPlus | INJURY | - |
dc.subject.keywordPlus | FIBROSIS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | RATS | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | INVOLVEMENT | - |
dc.subject.keywordAuthor | Reynosin | - |
dc.subject.keywordAuthor | Thioacetamide (TAA) | - |
dc.subject.keywordAuthor | Hepatocyte | - |
dc.subject.keywordAuthor | Apoptosis | - |
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