Transcutaneous antigen delivery system
- Authors
- Lee, Mi-Young; Shin, Meong-Cheol; Yang, Victor C.
- Issue Date
- 31-Jan-2013
- Publisher
- 생화학분자생물학회
- Keywords
- Antigen delivery; Epidermis; Transcutaneous immunization; Vaccine
- Citation
- BMB Reports, v.46, no.1, pp 17 - 24
- Pages
- 8
- Journal Title
- BMB Reports
- Volume
- 46
- Number
- 1
- Start Page
- 17
- End Page
- 24
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/13976
- DOI
- 10.5483/BMBRep.2013.46.1.001
- ISSN
- 1976-6696
1976-670X
- Abstract
- Transcutaneous immunization refers to the topical application of antigens onto the epidermis. Transcutaneous immunization targeting the Langerhans cells of the skin has received much attention due to its safe, needle-free, and noninvasive antigen delivery. The skin has important immunological functions with unique roles for antigen-presenting cells such as epidermal Langerhans cells and dermal dendritic cells. In recent years, novel vaccine delivery strategies have continually been developed; however, transcutaneous immunization has not yet been fully exploited due to the penetration barrier represented by the stratum corneum, which inhibits the transport of antigens and adjuvants. Herein we review recent achievements in transcutaneous immunization, focusing on the various strategies for the enhancement of antigen delivery and vaccination efficacy. [BMB Reports 2013; 46(1): 17-24]
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Collections - College of Medical Sciences > Department of Medical Biotechnology > 1. Journal Articles
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