Ratio of Angiopoietin-2 to Angiopoietin-1 predicts mortality in acute lung injury induced by paraquat
DC Field | Value | Language |
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dc.contributor.author | Choi, Jae-Sung | - |
dc.contributor.author | Kwak, Kyung-A | - |
dc.contributor.author | Park, Min-Ju | - |
dc.contributor.author | Kim, Young-Hee | - |
dc.contributor.author | Gil, Hyo-Wook | - |
dc.contributor.author | Song, Ho-yeon | - |
dc.contributor.author | Hong, Sae-yong | - |
dc.date.accessioned | 2021-08-12T01:25:49Z | - |
dc.date.available | 2021-08-12T01:25:49Z | - |
dc.date.issued | 2013-01-09 | - |
dc.identifier.issn | 1234-1010 | - |
dc.identifier.issn | 1643-3750 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/13978 | - |
dc.description.abstract | Background: To determine whether initial reactive oxygen species (ROS)-induced endothelial cell injury is involved in early death after paraquat intoxication and concentrations of angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2), and von Willebrand factor (VWF) reflecting endothelial cell injury, we investigated the initial endothelial cell injury marker involved in the pathogenesis of death within 5 days after paraquat ingestion. Material/Methods: Sixty patients with paraquat poisoning were prospectively enrolled. Plasma samples were collected at admission. Plasma concentrations of Ang-1, Ang-2, and VWF were measured by enzyme-linked immunosorbent assay. The patients were classified into 3 categories: survivors, early death (died within 5 days after ingestion), and late death (died more than 5 days after ingestion). Results: The baseline concentration of Ang-2 and the Ang-2: Ang-1 ratio were significantly higher in patients who died (Ang-2 [pg/mL], 1012.75 +/- 468.02 vs. 1986.07 +/- 1675.37 [p = 0.002]; Ang-2: Ang-1, 0.90 +/- 0.49 vs. 2.16 +/- 2.28 [p= 0.002]). The Ang-2: Ang-1 ratio was significantly higher in the early death group (2.41 +/- 2.54) than in the survivors (0.90 +/- 0.49) and the late death group (1.33 +/- 0.64). The Ang-2: Ang-1 ratio was significantly associated with early death (OR, 2.602; 95% CI, 1.106-6.117; p= 0.028) after adjusting for plasma levels of paraquat, age, PCO2, and creatinine. VWF did not predict mortality. Conclusions: Endothelial cell damage could be involved in the pathogenesis of early death following paraquat ingestion. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Medical Science International Publishing | - |
dc.title | Ratio of Angiopoietin-2 to Angiopoietin-1 predicts mortality in acute lung injury induced by paraquat | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.scopusid | 2-s2.0-84876829316 | - |
dc.identifier.wosid | 000319821400001 | - |
dc.identifier.bibliographicCitation | Medical Science Monitor, v.19, pp 28 - 33 | - |
dc.citation.title | Medical Science Monitor | - |
dc.citation.volume | 19 | - |
dc.citation.startPage | 28 | - |
dc.citation.endPage | 33 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.subject.keywordPlus | VON-WILLEBRAND-FACTOR | - |
dc.subject.keywordPlus | RESPIRATORY-DISTRESS-SYNDROME | - |
dc.subject.keywordPlus | FACTOR ANTIGEN LEVELS | - |
dc.subject.keywordPlus | CIRCULATING ANGIOPOIETIN-2 | - |
dc.subject.keywordPlus | PATHOGENETIC SIGNIFICANCE | - |
dc.subject.keywordPlus | AIRWAY INFLAMMATION | - |
dc.subject.keywordPlus | ENDOTHELIAL-CELLS | - |
dc.subject.keywordPlus | SEPSIS | - |
dc.subject.keywordPlus | PLASMA | - |
dc.subject.keywordPlus | SERUM | - |
dc.subject.keywordAuthor | paraquat | - |
dc.subject.keywordAuthor | acute lung injury | - |
dc.subject.keywordAuthor | angiopoietin | - |
dc.subject.keywordAuthor | endothelial cells | - |
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