Ratio of Angiopoietin-2 to Angiopoietin-1 predicts mortality in acute lung injury induced by paraquat
- Authors
- Choi, Jae-Sung; Kwak, Kyung-A; Park, Min-Ju; Kim, Young-Hee; Gil, Hyo-Wook; Song, Ho-yeon; Hong, Sae-yong
- Issue Date
- 9-Jan-2013
- Publisher
- Medical Science International Publishing
- Keywords
- paraquat; acute lung injury; angiopoietin; endothelial cells
- Citation
- Medical Science Monitor, v.19, pp 28 - 33
- Pages
- 6
- Journal Title
- Medical Science Monitor
- Volume
- 19
- Start Page
- 28
- End Page
- 33
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/13978
- ISSN
- 1234-1010
1643-3750
- Abstract
- Background: To determine whether initial reactive oxygen species (ROS)-induced endothelial cell injury is involved in early death after paraquat intoxication and concentrations of angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2), and von Willebrand factor (VWF) reflecting endothelial cell injury, we investigated the initial endothelial cell injury marker involved in the pathogenesis of death within 5 days after paraquat ingestion. Material/Methods: Sixty patients with paraquat poisoning were prospectively enrolled. Plasma samples were collected at admission. Plasma concentrations of Ang-1, Ang-2, and VWF were measured by enzyme-linked immunosorbent assay. The patients were classified into 3 categories: survivors, early death (died within 5 days after ingestion), and late death (died more than 5 days after ingestion). Results: The baseline concentration of Ang-2 and the Ang-2: Ang-1 ratio were significantly higher in patients who died (Ang-2 [pg/mL], 1012.75 +/- 468.02 vs. 1986.07 +/- 1675.37 [p = 0.002]; Ang-2: Ang-1, 0.90 +/- 0.49 vs. 2.16 +/- 2.28 [p= 0.002]). The Ang-2: Ang-1 ratio was significantly higher in the early death group (2.41 +/- 2.54) than in the survivors (0.90 +/- 0.49) and the late death group (1.33 +/- 0.64). The Ang-2: Ang-1 ratio was significantly associated with early death (OR, 2.602; 95% CI, 1.106-6.117; p= 0.028) after adjusting for plasma levels of paraquat, age, PCO2, and creatinine. VWF did not predict mortality. Conclusions: Endothelial cell damage could be involved in the pathogenesis of early death following paraquat ingestion.
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Collections - College of Medicine > Department of Internal Medicine > 1. Journal Articles
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