Association Analysis Between FILIP1 Polymorphisms and Aspirin Hypersensitivity in Korean Asthmatics
- Authors
- Kim, Jason Yongha; Kim, Jeong-Hyun; Park, Byung-Lae; Pasaje, Charisse Flerida A.; Bae, Joon Seal; Park, Sook; Jang, An-Soo; Uh, Soo-Taek; Kim, Yong-Hoon; Kim, Mi-Kyeong; Choi, Inseon S.; Cho, Sang Heon; Choi, Byoung Whui; Park, Choon-Sik; Shin, Hyoung Doo
- Issue Date
- Jan-2013
- Publisher
- 대한천식알레르기학회
- Keywords
- Filamin A interacting protein 1; single nucleotide polymorphism; haplotype; asthma; aspirin exacerbated respiratory disease
- Citation
- Allergy, Asthma & Immunology Research, v.5, no.1, pp 34 - 41
- Pages
- 8
- Journal Title
- Allergy, Asthma & Immunology Research
- Volume
- 5
- Number
- 1
- Start Page
- 34
- End Page
- 41
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/14072
- DOI
- 10.4168/aair.2013.5.1.34
- ISSN
- 2092-7355
2092-7363
- Abstract
- Purpose: Aspirin exacerbated respiratory disease (AERD) results in a severe asthma attack after aspirin ingestion in asthmatics. The filamin A interacting protein 1 (FILIP1) may play a crucial role in AERD pathogenesis by mediating T cell activation and membrane rearrangement. We investigated the association of FILIP1 variations with AERD and the fall rate of forced expiratory volume in one second (FEV1). Methods: A total of 34 common FILIP1 single nucleotide polymorphisms (SNPs) were genotyped in 592 Korean asthmatic subjects that included 163 AERD patients and 429 aspirin-tolerant asthma (ATA) controls. Results: This study found that 5 SNPs (P=0.006-0.01) and 2 haplotypes (P=0.01-0.03) of FILIP1 showed nominal signals; however, corrections for the multiple testing revealed no significant associations with the development of AERD (P-corr>0.05). In addition, association analysis of the genetic variants with the fall rate of FEV1, an important diagnostic marker of AERD, revealed no significant evidence (P-corr>0.05). Conclusions: Although further replications and functional evaluations are needed, our preliminary findings suggest that genetic variant of FILIP1 might be not associated with the onset of AERD.
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Collections - College of Medicine > Department of Internal Medicine > 1. Journal Articles
- College of Medicine > Department of Internal Medicine > 1. Journal Articles
- College of Medicine > Department of Internal Medicine > 1. Journal Articles
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