Triptolide Suppresses the Expression of Cyclooxygenase-2 Induced by Toll-Like Receptor 3 and 4 AgonistsTriptolide Suppresses the Expression of Cyclooxygenase-2 Induced by Toll-Like Receptor 3 and 4 Agonists
- Other Titles
- Triptolide Suppresses the Expression of Cyclooxygenase-2 Induced by Toll-Like Receptor 3 and 4 Agonists
- Authors
- 구교정; 엄상훈; 민인순; 윤형선
- Issue Date
- 2013
- Publisher
- 대한의생명과학회
- Keywords
- Toll-like receptors; Triptolide; NF-κB; COX-2; Polyriboinosinic polyribocytidylic acid
- Citation
- 대한의생명과학회지, v.19, no.2, pp.112 - 117
- Journal Title
- 대한의생명과학회지
- Volume
- 19
- Number
- 2
- Start Page
- 112
- End Page
- 117
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/14392
- Abstract
- Toll-like receptors (TLRs) recognize pathogen-associated molecular patterns (PAMPs) and regulate the activation of innate immunity. All TLR signaling pathways culminate in the activation of NF-κB, leading to the induction of inflammatory gene products such as cyclooxygenase-2 (COX-2). Triptolide (TP), a natural component of Tripterygium wilfordii Hook. F, has been used as folk remedies to treat many chronic diseases for many years. In the present report,we present biochemical evidence that TP inhibits the NF-κB activation induced by polyriboinosinic polyribocytidylic acid (Poly[I:C], TLR3 agonist) and lipopolysaccharide (LPS, TLR4 agonist). TP also inhibits COX-2 expression induced by Poly[I:C] and LPS. These results suggest that TP can modulate the immune responses regulated by TLR3 and TLR4signaling pathways.
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Collections - College of Medical Sciences > Department of Biomedical Laboratory Science > 1. Journal Articles
- College of Medical Sciences > Department of Health Administration and Management > 1. Journal Articles
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