(E)-1-(2-(2-nitrovinyl)phenyl)pyrrolidine inhibits Inducible Nitric Oxide Synthase Expression in RAW264.7 Macrophages Stimulated with Lipopolysaccharide(E)-1-(2-(2-nitrovinyl)phenyl)pyrrolidine inhibits Inducible Nitric Oxide Synthase Expression in RAW264.7 Macrophages Stimulated with Lipopolysaccharide
- Other Titles
- (E)-1-(2-(2-nitrovinyl)phenyl)pyrrolidine inhibits Inducible Nitric Oxide Synthase Expression in RAW264.7 Macrophages Stimulated with Lipopolysaccharide
- Authors
- 구교정; 엄상훈; 서창원; 고광오; 김대영; 윤형선
- Issue Date
- 2013
- Publisher
- 대한의생명과학회
- Keywords
- Cyclooxygenase-2; Lipopolysaccharide; NF-κB; Inducible nitric oxide synthase; (E)-1-(2-(2-nitrovinyl)phenyl)pyrrolidine
- Citation
- 대한의생명과학회지, v.19, no.2, pp.168 - 172
- Journal Title
- 대한의생명과학회지
- Volume
- 19
- Number
- 2
- Start Page
- 168
- End Page
- 172
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/14407
- Abstract
- Toll-like receptors (TLRs) play an important role for host defense against invading pathogens. TLR4 has been identified as the receptor for lipopolysaccharide (LPS), which is a cell wall component of gram-negative bacteria. The activation of TLR4 signaling by LPS leads to the activation of NF-κB and the expression of pro-inflammatory gene products such as cytokines, inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2). To evaluate the therapeutic potential of (E)-1-(2-(2-nitrovinyl)phenyl)pyrrolidine (NVPP), previously synthesized in our laboratory,NF-κB activation and iNOS and COX-2 expression induced by LPS were examined. NVPP inhibited the activation of NF-κB induced by LPS. NVPP also suppressed the iNOS expression induced by LPS but it did not suppress COX-2expression induced by LPS. These results suggest that NVPP has the specific mechanism for anti-inflammatory responses.
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Collections - College of Medical Sciences > Department of Biomedical Laboratory Science > 1. Journal Articles
- College of Natural Sciences > Department of Chemistry > 1. Journal Articles
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