꼬마선충에서 메밀 추출물에 의한 산화성 스트레스 저항성 증가 및 수명 연장 효과Buckwheat Extract Increases Resistance to Oxidative Stress and Lifespan in Caenorhabditis elegans
- Other Titles
- Buckwheat Extract Increases Resistance to Oxidative Stress and Lifespan in Caenorhabditis elegans
- Authors
- 김철규; 박상규
- Issue Date
- 2013
- Publisher
- 한국약용작물학회
- Keywords
- Buckwheat; Oxidative Stress; Lifespan; Fertility; C. elegans
- Citation
- 한국약용작물학회지, v.21, no.1, pp.1 - 6
- Journal Title
- 한국약용작물학회지
- Volume
- 21
- Number
- 1
- Start Page
- 1
- End Page
- 6
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/14543
- ISSN
- 1225-9306
- Abstract
- Buckwheat (Fagopyrum esculentum) has been known for having strong anti-oxidant, anti-mutagenic, and anti-carcinogenic activities. The free radical theory of aging, also known as the oxidative stress theory of aging, claims that cellular oxidative damage accumulated with time is a major causal factor of aging. In the present study, we investigated the effect of buckwheat extracts on resistance to oxidative stress and aging using Caenorhabditis elegans as a model system. Survival under an oxidative-stress condition induced by paraquat increased markedly following 500㎎/L buckwheat extracts treatment, suggesting lower cellular oxidative damage by buckwheat extracts. A lifespan assay also revealed that treatment of buckwheat extracts significantly extended both the mean and maximum lifespan in C. elegans. Interestingly, this lifespanextension by buckwheat extracts was not accompanied by reduced fertility. These findings suggest that buckwheat extracts can confer longevity phenotype to C. elegans through its strong anti-oxidant activity and support the aging theory which emphasizes a pivotal role of oxidative stress during aging.
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Collections - College of Medical Sciences > Department of Medical Biotechnology > 1. Journal Articles
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